甲基化CpG结合蛋白在癌症中的作用
The Roles of the Methyl-CpG Binding Proteins in Cancer.
作者信息
Parry Lee, Clarke Alan R
机构信息
School of Biosciences, Cardiff University, Cardiff, UK.
出版信息
Genes Cancer. 2011 Jun;2(6):618-30. doi: 10.1177/1947601911418499.
Abstract
The methyl-CpG binding proteins (MBPs) interpret the methylation of DNA and its components. The number of MBPs in the human body currently stands at 15, which are split into 3 branches, a reflection of the intricate mechanisms of gene regulation. Each branch utilizes a different mechanism for interacting with methylated DNA or its components. These interactions function to direct gene expression and maintain or alter DNA architecture. It is these functions that are commonly exploited in human disease. For this review, we will focus on each protein and any roles it may have in initiating, promoting, progressing, or inhibiting cancer. This will highlight common threads in the roles of these proteins, which will allow us to speculate on potentially productive directions for future research.
摘要
甲基化CpG结合蛋白（MBPs）解读DNA及其成分的甲基化情况。目前人体内甲基化CpG结合蛋白的数量为15种，它们分为3个分支，这反映了基因调控机制的复杂性。每个分支利用不同的机制与甲基化DNA或其成分相互作用。这些相互作用起到指导基因表达以及维持或改变DNA结构的作用。正是这些功能在人类疾病中常常被利用。在本综述中，我们将聚焦于每种蛋白及其在引发、促进、进展或抑制癌症方面可能具有的任何作用。这将突出这些蛋白作用中的共同线索，使我们能够推测未来研究可能富有成效的方向。
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