Key Laboratory of Ethnic Medicine Resource Chemistry, State Ethnic Affairs Commission and Ministry of Education, School of Chemistry and Biotechnology, Yunnan University of Nationalities, Kunming 650031, China.
Nat Prod Res. 2012;26(20):1876-80. doi: 10.1080/14786419.2011.619190. Epub 2011 Sep 26.
A novel lignan glysocide, namely sagitiside A (1), together with two known ones, (+)-lyoniresinol-2α-O-β-D-glucopyranoside (2) and (+)-5'-methoxyisolariciresinol 3α-O-β-D-glucopyranoside (3), was isolated from the 95% ethanol extract of dry roots of Tinospora sagittata var. yunnanensis. The structure of the new compound (1) was determined based on MS, 1D and 2D NMR spectral data. Compounds 1-3 showed antioxidant activity with EC(50) values 55, 75 and 80 µM by 1,1-diphenyl-2-picryhydrazyl (DPPH) radical-scavenging assay.
从云南三叶苦干根的 95%乙醇提取物中分离得到一个新的木脂素糖苷，即 sagitiside A（1），以及另外两个已知化合物，（+）-lyoniresinol-2α-O-β-D-吡喃葡萄糖苷（2）和（+）-5'-甲氧基异松脂素 3α-O-β-D-吡喃葡萄糖苷（3）。根据 MS、1D 和 2D NMR 光谱数据确定了新化合物（1）的结构。化合物 1-3 通过 1,1-二苯基-2-苦基肼（DPPH）自由基清除试验显示出抗氧化活性，EC（50）值分别为 55、75 和 80 μM。
