Department of Biology, Faculty of Chemistry, National Autonomous University of Mexico, Mexico City, Mexico.
J Med Food. 2011 Nov;14(11):1370-4. doi: 10.1089/jmf.2010.0238. Epub 2011 Sep 23.
This study was designed to investigate if α-mangostin (α-M), a xanthone present in the pericarp of Garcinia mangostana L., was able to protect against reperfusion injury in Langendorff-reperfused hearts. It was observed that α-M maintains the cardiac mechanical work, diminishes the area of infarct, and prevents the decrease in cardiac ATP and phosphocreatine levels in the reperfused myocardium. The protective effect of this xanthone was associated with reduction of oxidative stress. α-M treatment prevented reperfusion injury-induced protein oxidation (protein carbonyl content), lipid peroxidation (malondialdehyde and 4-hydroxynonenal content), and diminution of glutathione content. In fact, after α-M treatment, the values in these parameters were comparable to those obtained in nonreperfused hearts. In summary, α-M induces a protective effect in postischemic heart associated to the prevention of oxidative stress secondary to reperfusion injury.
本研究旨在探讨是否α-倒捻子素（α-M），一种存在于藤黄果皮中的呫吨酮，能够预防 Langendorff 再灌注心脏的再灌注损伤。结果表明，α-M 能维持心脏机械功，减少梗死面积，并防止再灌注心肌中 ATP 和磷酸肌酸水平的降低。这种呫吨酮的保护作用与减少氧化应激有关。α-M 处理可预防再灌注损伤诱导的蛋白质氧化（蛋白质羰基含量）、脂质过氧化（丙二醛和 4-羟基壬烯醛含量）和谷胱甘肽含量降低。事实上，α-M 处理后，这些参数的值与未再灌注心脏获得的值相当。总之，α-M 诱导缺血后心脏产生保护作用，与预防再灌注损伤引起的氧化应激有关。
