"Victor Babes" National Institute of Pathology , Bucharest , Romania.
Biomarkers. 2011 Nov;16(7):587-9. doi: 10.3109/1354750X.2011.611597. Epub 2011 Sep 26.
A significant proportion of heart failure (HF) patients have preserved ejection fraction (EF). Considering that inflammation and oxidative stress are involved in HF evolution, we investigated lipoprotein-associated phospholipase A2 (LpPLA2), an enzyme involved in these pathophysiologic processes in relation to EF.
The study included 208 HF patients and 20 healthy controls. HF patients with preserved EF (HFpEF) represented 42.31% of all HF patients. LpPLA2 activity was significantly increased in HF patients when compared with controls and was higher in HFpEF than in HF with reduced EF patients (HFrEF). The incidence of left ventricular hypertrophy was higher in HFpEF than in HFrEF (EF < 50).
Confirming its role as a marker of vascular inflammation, LpPLA2 seems to be a biomarker constantly correlated with HF, regardless of etiology. Elevated plasma values of LpPLA2 in HFpEF are consistent with the exacerbated inflammatory status.
相当一部分心力衰竭（HF）患者射血分数保留（EF）。考虑到炎症和氧化应激参与 HF 的发展，我们研究了脂蛋白相关磷脂酶 A2（LpPLA2），一种与这些病理生理过程相关的酶，与 EF 有关。
本研究纳入 208 例 HF 患者和 20 例健康对照者。EF 保留的心力衰竭（HFpEF）患者占所有 HF 患者的 42.31%。与对照组相比，HF 患者的 LpPLA2 活性显著升高，HFpEF 患者的 LpPLA2 活性高于射血分数降低的心力衰竭（HFrEF）患者。HFpEF 患者左室肥厚的发生率高于 HFrEF（EF < 50）。
证实其作为血管炎症标志物的作用，LpPLA2 似乎是一种与心力衰竭相关的标志物，无论病因如何。HFpEF 中升高的 LpPLA2 血浆值与炎症状态的加剧一致。
