Detopoulou Paraskevi, Nomikos Tzortzis, Fragopoulou Elizabeth, Chrysohoou Christina, Antonopoulou Smaragdi
Department of Nutrition, General Hospital Korgialenio-Benakio, Athanasaki 1, Athens, Greece.
Curr Heart Fail Rep. 2013 Jun;10(2):122-9. doi: 10.1007/s11897-013-0131-2.
Heart failure (HF) is a complex syndrome with cardiac, renal, neurohormonal and sympathetic nervous system's manifestations, the pathogenesis of which among others is connected to inflammation. PAF has local and systemic effects pertaining to HF progression since it causes a negative inotropic effect, it induces arrhythmias, it induces apoptosis and it is involved in inflammation and atherosclerosis. In the present review the role of PAF in HF will be thoroughly presented along with the relevant data on PAF enzymes and the potential role of PAF metabolic circuit as a novel pharmacological target.
心力衰竭（HF）是一种具有心脏、肾脏、神经激素和交感神经系统表现的复杂综合征，其发病机制尤其与炎症有关。血小板活化因子（PAF）对HF进展具有局部和全身作用，因为它会引起负性肌力作用、诱发心律失常、诱导细胞凋亡，并且参与炎症和动脉粥样硬化。在本综述中，将全面介绍PAF在HF中的作用以及关于PAF酶的相关数据，以及PAF代谢途径作为一种新型药理学靶点的潜在作用。
