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Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics.

作者信息

Merrill Alfred H

机构信息

School of Biology, and the Petit Institute for Bioengineering and Biosciences, Georgia Institute of Technology, Atlanta, Georgia 30332-0230, USA.

出版信息

Chem Rev. 2011 Oct 12;111(10):6387-422. doi: 10.1021/cr2002917. Epub 2011 Sep 26.

DOI:10.1021/cr2002917
PMID:21942574
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3191729/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/6422d879189c/cr-2011-002917_0039.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/0aa0afe72110/cr-2011-002917_0029.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/12748c017f20/cr-2011-002917_0030.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/9a2f24ac1e00/cr-2011-002917_0031.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/9bf2158e4872/cr-2011-002917_0032.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/61b8723d7d62/cr-2011-002917_0033.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/11727740e75a/cr-2011-002917_0034.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/ac8d479080b5/cr-2011-002917_0035.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/bfe8e8c201e5/cr-2011-002917_0036.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/da6afcd97501/cr-2011-002917_0037.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/f2d6398dda40/cr-2011-002917_0038.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/6422d879189c/cr-2011-002917_0039.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/0aa0afe72110/cr-2011-002917_0029.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/12748c017f20/cr-2011-002917_0030.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/9a2f24ac1e00/cr-2011-002917_0031.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/9bf2158e4872/cr-2011-002917_0032.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/61b8723d7d62/cr-2011-002917_0033.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/11727740e75a/cr-2011-002917_0034.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/ac8d479080b5/cr-2011-002917_0035.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/bfe8e8c201e5/cr-2011-002917_0036.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/da6afcd97501/cr-2011-002917_0037.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/f2d6398dda40/cr-2011-002917_0038.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/dda8/3191729/6422d879189c/cr-2011-002917_0039.jpg

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Analysis of mammalian sphingolipids by liquid chromatography tandem mass spectrometry (LC-MS/MS) and tissue imaging mass spectrometry (TIMS).通过液相色谱串联质谱法（LC-MS/MS）和组织成像质谱法（TIMS）分析哺乳动物鞘脂。
Biochim Biophys Acta. 2011 Nov;1811(11):838-53. doi: 10.1016/j.bbalip.2011.06.027. Epub 2011 Jul 1.
3
Encephalopathy caused by ablation of very long acyl chain ceramide synthesis may be largely due to reduced galactosylceramide levels.
Front Aging Neurosci. 2025 Jul 7;17:1561831. doi: 10.3389/fnagi.2025.1561831. eCollection 2025.
4
Stereocontrolled Ring-Opening of Oxazolidinone-Fused Aziridines for the Synthesis of 2-Amino Ethers.用于合成2-氨基醚的恶唑烷酮稠合氮丙啶的立体控制开环反应
J Org Chem. 2025 Jul 18;90(28):10017-10030. doi: 10.1021/acs.joc.5c01068. Epub 2025 Jul 7.
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Sphingolipids and Male Reproductive Health: A Narrative Review of Their Roles in Spermatogenesis, Fertility, and Dysfunction.鞘脂与男性生殖健康：关于其在精子发生、生育能力及功能障碍中作用的叙述性综述
Reprod Sci. 2025 Jun 12. doi: 10.1007/s43032-025-01898-4.
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Apolipoprotein M expression modifies the sphingolipid landscape in murine blood and lymph.载脂蛋白M的表达改变了小鼠血液和淋巴中的鞘脂格局。
Front Immunol. 2025 May 2;16:1572959. doi: 10.3389/fimmu.2025.1572959. eCollection 2025.
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Metabolic and Structural Consequences of GM3 Synthase Deficiency: Insights from an HEK293-T Knockout Model.GM3合酶缺乏的代谢和结构后果：来自HEK293-T基因敲除模型的见解
Biomedicines. 2025 Apr 1;13(4):843. doi: 10.3390/biomedicines13040843.
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Glycosphingolipids as emerging attack points in bladder cancer.糖鞘脂作为膀胱癌新出现的攻击靶点。
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Region-specific quantitation of glycosphingolipids in the elderly human brain with Nanoflow MEA Chip Q/ToF mass spectrometry.使用纳流MEA芯片Q/ToF质谱法对老年人大脑特定区域的糖鞘脂进行定量分析。
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由于非常长链酰基鞘氨醇合成的消融而导致的脑病可能在很大程度上是由于半乳糖神经酰胺水平降低所致。
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Novel pathway of ceramide production in mitochondria: thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-CoA.线粒体中神经酰胺产生的新途径：硫酯酶和中性神经酰胺酶从鞘氨醇和酰基辅酶 A 产生神经酰胺。
J Biol Chem. 2011 Jul 15;286(28):25352-62. doi: 10.1074/jbc.M110.214866. Epub 2011 May 25.