Crawford J M
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
Semin Diagn Pathol. 1990 May;7(2):115-28.
Recent developments in the pathologic assessment of several benign hepatic processes are reviewed, with particular emphasis on distinguishing these processes from malignant lesions. Liver cell dysplasia remains a controversial lesion, with mounting evidence to support its preneoplastic nature. Adenomatous hyperplastic nodules are large regenerative nodules in cirrhotic livers, and may also have malignant potential. Distinguishing these nodules from hepatocellular carcinoma by histology may become increasingly important, with the advent of more sensitive imaging techniques. Differentiating features of noncancerous biliary epithelium versus well-differentiated cholangiocarcinoma, sclerosing hemangioma versus epithelioid hemangioendothelioma, and angiomyelolipoma versus the clear cell variant of hepatocellular carcinoma are also presented and discussed.
本文综述了几种良性肝脏病变病理评估的最新进展，尤其着重于将这些病变与恶性病变相鉴别。肝细胞发育异常仍是一个存在争议的病变，越来越多的证据支持其癌前性质。腺瘤样增生结节是肝硬化肝脏中的大再生结节，也可能具有恶性潜能。随着更敏感成像技术的出现，通过组织学将这些结节与肝细胞癌区分开来可能变得越来越重要。本文还介绍并讨论了非癌性胆管上皮与高分化胆管癌、硬化性血管瘤与上皮样血管内皮瘤、血管平滑肌脂肪瘤与肝细胞癌透明细胞变体的鉴别特征。
