Eck Institute for Global Health, Department of Biological Sciences, University of Notre Dame, Notre Dame, Indiana 46556, USA.
Annu Rev Entomol. 2012;57:143-66. doi: 10.1146/annurev-ento-120710-100651. Epub 2011 Sep 19.
The whole-genome sequencing of mosquitoes has facilitated our understanding of fundamental biological processes at their basic molecular levels and holds potential for application to mosquito control and prevention of mosquito-borne disease transmission. Draft genome sequences are available for Anopheles gambiae, Aedes aegypti, and Culex quinquefasciatus. Collectively, these represent the major vectors of African malaria, dengue fever and yellow fever viruses, and lymphatic filariasis, respectively. Rapid advances in genome technologies have revealed detailed information on genome architecture as well as phenotype-specific transcriptomics and proteomics. These resources allow for detailed comparative analyses within and across populations as well as species. Next-generation sequencing technologies will likely promote a proliferation of genome sequences for additional mosquito species as well as for individual insects. Here we review the current status of genome research in mosquitoes and identify potential areas for further investigations.
蚊子的全基因组测序促进了我们对基本分子水平的基本生物学过程的理解，并有可能应用于蚊子控制和预防蚊子传播的疾病。冈比亚按蚊、埃及伊蚊和致倦库蚊的基因组草图序列已经可用。这些蚊子分别代表了非洲疟疾、登革热和黄热病病毒以及淋巴丝虫病的主要传播媒介。基因组技术的快速发展揭示了有关基因组结构以及表型特异性转录组学和蛋白质组学的详细信息。这些资源允许在种群内和种群间以及物种间进行详细的比较分析。下一代测序技术可能会促进更多蚊子物种以及单个昆虫的基因组序列的大量出现。在这里，我们回顾了蚊子基因组研究的现状，并确定了进一步研究的潜在领域。
