Department of Psychiatry, University of Basel, Basel, Switzerland.
Schizophr Res. 2011 Dec;133(1-3):63-7. doi: 10.1016/j.schres.2011.08.021. Epub 2011 Sep 22.
Despite many neuroimaging studies on schizophrenia showing brain abnormalities the exact time course of their occurrence is unknown. Studies of gray matter are a powerful tool in biological psychiatry and provide an unprecedented opportunity for brain structure investigations. Here we compared cross-sectional and longitudinal structural neuroimaging studies distinguishing high-risk subjects developing psychosis from those who did not. These investigations on gray matter volumes in the prodromal phase potentially identify core structural markers of impending psychoses and clarify dynamic changes underlying the transition. Subjects at high risk of psychosis show qualitatively similar albeit less severe gray matter abnormalities as patients with psychosis.
尽管许多关于精神分裂症的神经影像学研究显示大脑存在异常，但它们的确切发生时间尚不清楚。 灰质研究是生物精神病学中的有力工具，为脑结构研究提供了前所未有的机会。 在这里，我们比较了区分发生精神病和未发生精神病的高风险受试者的横断面和纵向结构神经影像学研究。 这些在前驱期的灰质体积研究可能确定潜在精神病的核心结构标记物，并阐明过渡的动态变化。 有精神病风险的受试者表现出与精神病患者相似的，尽管程度较轻的灰质异常。
