Department of Ophthalmology, Faculty of Medicine, Chiang Mai University, 110 Intawaroros Road, Chiang Mai 50200, Thailand.
Trans R Soc Trop Med Hyg. 2011 Nov;105(11):650-4. doi: 10.1016/j.trstmh.2011.08.003. Epub 2011 Sep 23.
Uveitis is a major cause of severe visual impairment throughout the world and can be initiated by various infectious and non-infectious causes. Early recognition of specific infections is important as the treatment with antimicrobial agents might stop the progression or even cure the eye disease. To determine the infectious causes of uveitis in Thailand, intraocular fluid samples of 100 HIV-negative patients and 47 HIV-positive patients with uveitis were examined using real-time PCR analysis for herpes simplex virus, varicella zoster virus, cytomegalovirus and Toxoplasma gondii. Positive PCR results were found in 33/100 (33%) HIV-negative patients and in 33/47 (70%) HIV-positive patients with uveitis. In Thailand, cytomegalovirus was identified as the most frequent cause of infectious uveitis in both HIV-negative and HIV-positive patients (49 and 91%, respectively). PCR analysis of intraocular samples in uveitis was a valuable diagnostic assay. The pattern of uveitis observed in the Far East differs from that found in the West.
葡萄膜炎是全世界范围内导致严重视力损害的主要原因，可由各种感染性和非感染性原因引起。早期识别特定的感染非常重要，因为使用抗菌药物治疗可能会阻止疾病的进展，甚至治愈眼部疾病。为了确定泰国葡萄膜炎的感染原因，对 100 例 HIV 阴性和 47 例 HIV 阳性葡萄膜炎患者的眼内液样本进行了实时 PCR 分析，以检测单纯疱疹病毒、水痘带状疱疹病毒、巨细胞病毒和弓形体。在 100 例 HIV 阴性患者中有 33 例（33%）和在 47 例 HIV 阳性葡萄膜炎患者中有 33 例（70%）PCR 检测结果为阳性。在泰国，巨细胞病毒是 HIV 阴性和 HIV 阳性患者感染性葡萄膜炎的最常见原因（分别为 49%和 91%）。眼内样本的 PCR 分析是一种有价值的诊断方法。在远东观察到的葡萄膜炎模式与西方不同。
