Kahn A, Brachet E
Prostaglandins. 1978 Dec;16(6):939-44. doi: 10.1016/0090-6980(78)90109-0.
Prostaglandins (PG) have been shown to raise the level of cyclic AMP (cAMP) in various tissues, and to increase permeability. Whether both events are linked, is at present a matter of speculation. We have investigated the effects of PGE1, E2, A1, A2, F1alpha and F2alpha on an isolated rat mesentery placed in a diffusion cell (surface area : 2 sq.cm). The PGs (5 microgram/ml) increased the passage of (I 125) - Albumin across the mesentery. In other experiments, diks of rat mesentery (surface area : 2 sq.cm) have been incubated in assay tubes, and cAMP levels measured by a binding protein assay. We have observed an excellent correlation between increases in permeability and cAMP levels (r=0.961). In order of increasing potency on both parameters, the PGs may be classified as follows : PGF, PGA and PGE. In the rat mesentery, under the influence of prostaglandins, increases in permeability and in cAMP levels are apparently connected.
前列腺素（PG）已被证明可提高多种组织中环磷酸腺苷（cAMP）的水平，并增加通透性。目前尚不清楚这两个事件是否相关。我们研究了前列腺素E1、E2、A1、A2、F1α和F2α对置于扩散池中（表面积：2平方厘米）的离体大鼠肠系膜的影响。前列腺素（5微克/毫升）增加了（碘125）白蛋白穿过肠系膜的量。在其他实验中，将大鼠肠系膜片（表面积：2平方厘米）置于试管中孵育，并用结合蛋白分析法测量cAMP水平。我们观察到通透性增加与cAMP水平之间存在良好的相关性（r = 0.961）。按照对这两个参数效力增加的顺序，前列腺素可分类如下：前列腺素F、前列腺素A和前列腺素E。在大鼠肠系膜中，在前列腺素的影响下，通透性增加和cAMP水平增加显然是相关的。
