School of Nursing and Departments of Anesthesia and Critical Care Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
Respir Care. 2011 Sep;56(9):1247-54; discussion 1254-7. doi: 10.4187/respcare.01255.
Pediatric clinicians strive to base their management decisions on best available evidence. In the quantitative research paradigm, the highest level of evidence is derived from a conclusive randomized controlled clinical trial (RCT). Currently, there are few adequately powered RCTs to support pediatric acute respiratory care, but this landscape is changing. We are all obligated to ensure the relevance of our research, to mentor junior investigators, and to support knowledge development in our field. This paper reviews the hurdles faced by clinical investigators in the field of pediatric critical care and offers suggestions for future clinical studies.
儿科临床医生努力根据最佳现有证据做出管理决策。在定量研究范式中，最高级别的证据来自结论性的随机对照临床试验（RCT）。目前，很少有足够有力的 RCT 来支持儿科急性呼吸护理，但这种情况正在发生变化。我们都有义务确保我们的研究具有相关性，指导初级研究人员，并支持我们领域的知识发展。本文回顾了儿科危重病领域临床研究人员面临的障碍，并为未来的临床研究提出了建议。
