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不稳定儿科血液肿瘤患者的管理:对西班牙儿科肿瘤学家进行的基于网络的调查结果。

Management of unstable pediatric hemato-oncology patient: results of a Web-based survey to pediatric oncologists in Spain.

机构信息

Pediatric Critical Care Unit, Hospital Infantil Universitario Niño Jesús, Avenida Menéndez Pelayo 65, Madrid, Spain.

出版信息

Eur J Pediatr. 2013 Jan;172(1):51-8. doi: 10.1007/s00431-012-1840-3. Epub 2012 Sep 27.

DOI:10.1007/s00431-012-1840-3
PMID:23015044
Abstract

UNLABELLED

The current management and monitoring of unstable pediatric hemato-oncology patient (UPHOP) in the oncology ward is not well defined. To evaluate this concept, an anonymous Web-based survey was sent to the 150 Spanish pediatric oncologists registered in the Spanish Society of Pediatric Hemato-Oncology. The response rate was 57 %, with the following main results: Pediatric intensive consulting was available for 97 %, and it was made in case of UPHOP by 37 % of oncologists, up to 65 % if hemodynamic instability. In case of inotropic support initiation, 32 % of respondents never consulted the intensivist. Dopamine is first chosen inotropic; 28 % of surveyed considered there is no limit in its dosage or it is superior to 20 μg/kg/min before an intensivist consulting. Pediatric intensive care admission was considered necessary in case of fever with hemodynamic instability by 15 % of respondents. Respiratory monitoring was mainly done by clinical signs (67 %). In case of respiratory insufficiency, the noninvasive respiratory support by high-flow ventilation with nasal cannula was applied by 57 % in the oncology ward. In case of acute kidney injury, diuretics were generally the initial therapy. The anticonvulsive drugs most frequently applied were valproic acid (93 %), diazepam (88 %), and phenytoin (81 %).

CONCLUSION

A consensus should be achieved among oncologists and intensivists. The creation and training of rapid response teams could be useful to improve the UPHOP management.

摘要

目的

不稳定儿科血液肿瘤患者(UPHOP)在肿瘤科病房的管理和监测尚不完善。为了评估这一概念,我们对西班牙儿科血液肿瘤学会注册的 150 名西班牙儿科肿瘤学家进行了一项匿名网络调查。回复率为 57%,主要结果如下:97%的医院配备了小儿重症监护咨询服务,如果 UPHOP 出现血流动力学不稳定,37%的肿瘤学家会咨询重症监护医生,而如果出现血流动力学不稳定,65%的肿瘤学家会咨询重症监护医生。在开始使用正性肌力支持时,32%的受访者从未咨询过重症监护医生。多巴胺是首选的正性肌力药物;28%的受访者认为在咨询重症监护医生之前,多巴胺没有剂量限制或其剂量优于 20μg/kg/min。15%的受访者认为在发热伴血流动力学不稳定时需要入住儿科重症监护病房。呼吸监测主要通过临床体征进行(67%)。如果出现呼吸功能不全,肿瘤科病房会通过鼻塞高流量通气进行无创呼吸支持,57%的受访者会采用这种方式。在出现急性肾损伤时,利尿剂通常是初始治疗药物。最常应用的抗惊厥药物是丙戊酸(93%)、地西泮(88%)和苯妥英(81%)。

结论

肿瘤学家和重症监护医生之间应达成共识。快速反应团队的建立和培训可能有助于改善 UPHOP 的管理。

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