Wan Liang-cai, Xie Min-qiang, Fu Xiao-yi, Jiang Shan-shan, Xian Xian-qing
Department of Otolaryngology, Southern Medical University, Guangzhou 510282, China.
Nan Fang Yi Ke Da Xue Xue Bao. 2011 Sep;31(9):1521-5.
To develop a transparent, non-toxic, non-irritating anti-fogging agent with long-lasting effect for nasal endoscopy.
The anti-fogging agent was prepared by mixing ethanol, propylene glycol, polyoxyethylene lauryl ether, sodium dodecyl sulfate, polyethylene glycol 400 and deionized water at different proportions based on an orthogonal test design. Twenty-seven test samples of the anti-fogging agents were obtained, which were colorless, transparent, and non-irritating, with a pH value of 7-8. Storz00 nasal endoscopy and its imaging system were used to test the anti-fogging time of the 27 samples, and each agent was tested for 3 times with medical Seoul iodine and 95% ethanol as control.
The optimal composition of the anti-fogging agent was 20% ethanol, 10% propylene glycol, 20% polyoxyethylene lauryl ether, 4% sodium dodecyl sulfate, 4% polyethylene glycol, 42% deionized water. The anti-fogging time of this agent reached 15 min, significantly longer than that of medical Seoul iodine (4 min) and 95% ethanol (18 s).
This anti-fogging agent for nasal endoscopes is colorless and safe and has a long anti-fogging time by forming a homogenous transparent membrane over the endoscopic lens.
研发一种用于鼻内镜检查的具有持久效果的透明、无毒、无刺激性的防雾剂。
基于正交试验设计，将乙醇、丙二醇、聚氧乙烯月桂醚、十二烷基硫酸钠、聚乙二醇400和去离子水按不同比例混合制备防雾剂。获得了27个防雾剂测试样品，它们无色、透明且无刺激性，pH值为7 - 8。使用Storz00鼻内镜及其成像系统测试这27个样品的防雾时间，每个样品以医用碘伏和95%乙醇作为对照进行3次测试。
防雾剂的最佳组成为20%乙醇、10%丙二醇、20%聚氧乙烯月桂醚、4%十二烷基硫酸钠、4%聚乙二醇、42%去离子水。该防雾剂的防雾时间达到15分钟，显著长于医用碘伏（4分钟）和95%乙醇（18秒）。
这种鼻内镜用防雾剂无色且安全，通过在内镜镜片上形成均匀的透明膜而具有较长的防雾时间。
