Genetics Department, National Institutes of Geriatrics, Beijing Hospital, Ministry of Health P.R. China.
Exp Gerontol. 2011 Dec;46(12):987-93. doi: 10.1016/j.exger.2011.09.001. Epub 2011 Sep 16.
Human longevity is a complex heritable genetic trait. Based on substantial evidence from model organisms, it is clear that mitochondria play a pivotal role in aging and lifespan. However, the effects that mitochondrial genome variations have upon longevity and longevity-related phenotypes in Chuang people in China have yet to be established. By genotyping 15 variants for 10 haplogroups in 738 Chuang subjects, including 367 long-lived individuals and 371 controls, we found that haplogroup F was significantly associated with longevity in females of Zhuang population of China (p=0.003, OR: 2.01, 95%CI: 1.263-3.197). Additionally, haplogroup F was related to higher HDL levels (p<0.05) in long-lived individuals. Further analysis suggests that the non-synonymous variant m.13928G>C in haplogroup F was also associated with longevity in female Zhuang Chinese which might account for the beneficial effect of F.
人类的长寿是一种复杂的遗传性特征。基于模式生物的大量证据，线粒体在衰老和寿命中起着关键作用。然而，线粒体基因组变异对中国壮族人群的长寿和与长寿相关表型的影响尚未确定。通过对 738 名壮族受试者的 10 个单倍群中的 15 个变体进行基因分型，包括 367 名长寿个体和 371 名对照，我们发现单倍群 F 与中国壮族女性的长寿显著相关（p=0.003，OR：2.01，95%CI：1.263-3.197）。此外，单倍群 F 还与长寿个体的更高 HDL 水平相关（p<0.05）。进一步的分析表明，单倍群 F 中的非同义变异 m.13928G>C 也与中国壮族女性的长寿相关，这可能解释了 F 的有益作用。
