The Biofilm Research Laboratory, The Bar-Ilan Institute of Nanotechnology and Advanced Materials, The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan, Israel.
Nanomedicine. 2012 Jul;8(5):702-11. doi: 10.1016/j.nano.2011.09.002. Epub 2011 Sep 21.
Antibiotic resistance has prompted the search for new agents that can inhibit bacterial growth. We recently reported on the antimicrobial and antibiofilm activities of nanosized magnesium fluoride (MgF(2)) nanoparticles (NPs) synthesized in ionic liquid using microwave chemistry. In this article, we describe a novel water-based synthesis of MgF(2) NPs using sonochemistry. The sonochemical irradiation of an aqueous solution of [Mg(OAc)(2)⋅(H(2)O)(4)] containing acidic HF as the fluorine ion source afforded crystalline well-shaped spherical MgF(2) NPs that showed much improved antibacterial properties against two common bacterial pathogens (Escherichia coli and Staphylococcus aureus). We were also able to demonstrate that the antimicrobial activity was dependent on the size of the NPs. In addition, using the described sonochemical process, we coated glass surfaces and demonstrated inhibition of bacterial colonization for 7 days. Finally, the antimicrobial activity of MgF(2) NPs against established biofilms was also examined. Taken together our results highlight the potential to further develop the concept of utilizing these metal fluoride NPs as novel antimicrobial and antibiofilm agents.
In this article, the authors describe a novel aqueous synthesis of magnesium fluoride NPs using sonochemistry. These nanoparticles have improved antibacterial and antibiofilm activity compared to their counterparts with traditional synthesis methods.
抗生素耐药性促使人们寻找能够抑制细菌生长的新药物。我们最近报道了使用微波化学在离子液体中合成的纳米氟化镁 (MgF2) 纳米粒子 (NPs) 的抗菌和抗生物膜活性。在本文中，我们描述了一种使用超声化学的新型水基 MgF2 NPs 合成方法。将含有酸性 HF 的 [Mg(OAc)2⋅(H2O)4] 的水溶液进行超声辐射，作为氟离子源，得到结晶良好的球形 MgF2 NPs，对两种常见的细菌病原体（大肠杆菌和金黄色葡萄球菌）具有更好的抗菌性能。我们还能够证明抗菌活性取决于 NPs 的大小。此外，使用所描述的超声化学过程，我们对玻璃表面进行了涂层，并证明了对细菌定植的抑制作用可持续 7 天。最后，还研究了 MgF2 NPs 对已建立的生物膜的抗菌活性。综上所述，我们的研究结果突出了进一步开发利用这些金属氟化物 NPs 作为新型抗菌和抗生物膜剂的潜力。
在本文中，作者描述了一种使用超声化学的新型水基氟化镁 NPs 合成方法。与传统合成方法相比，这些纳米粒子具有更好的抗菌和抗生物膜活性。
