Iznak A F, Iznak E V, Sorokin S A
Zh Nevrol Psikhiatr Im S S Korsakova. 2011;111(7):49-53.
The aim of the study was to reveal changes in the brain's functional state of patients with apathic depression, aged 20-51 years, during the treatment. Spectral parameters of background EEG as well as latencies of simple sensorimotor reaction and of two-alternative choice reaction to auditory stimuli have been analyzed. The complex reorganization of EEG spatial-frequency structure at the stage of pronounced clinical improvement was noticed. It included the EEG signs of the facilitation of inhibitory processes (seen as the increase of slow wave delta, theta-1 and theta-2 spectral power) mainly in frontal, central and temporal areas of the right hemisphere; the EEG signs of decreased activation of temporal areas (seen as the decrease of beta spectral power mainly in the right hemisphere), as well as the EEG signs of increased activation of anterior cortical areas by excitatory brain stem reticular structures (seen as the increase of beta spectral power in left frontal and central zones). The mean values of latencies of both simple sensorimotor reaction and of two-alternative choice reaction have been decreased as well. The data obtained are in line with contemporary views on the predominant role of the right hemisphere in the regulation of negative emotions and in the pathogenesis of depression.
本研究的目的是揭示年龄在20至51岁之间的无动性缄默型抑郁症患者在治疗期间大脑功能状态的变化。分析了背景脑电图的频谱参数以及对听觉刺激的简单感觉运动反应和二选一反应的潜伏期。在明显的临床改善阶段，观察到脑电图空间频率结构的复杂重组。它包括抑制过程促进的脑电图迹象（表现为右半球额叶、中央和颞叶区域慢波δ、θ-1和θ-2频谱功率增加）；颞叶区域激活减少的脑电图迹象（表现为主要在右半球β频谱功率降低），以及兴奋性脑干网状结构使前皮质区域激活增加的脑电图迹象（表现为左额叶和中央区域β频谱功率增加）。简单感觉运动反应和二选一反应潜伏期的平均值也有所降低。获得的数据与当代关于右半球在调节负面情绪和抑郁症发病机制中起主要作用的观点一致。
