Iznak A F, Tiganov A S, Iznak E V, Sorokin S A
Fiziol Cheloveka. 2013 Jul-Aug;39(4):49-57.
An analysis of EEG spectral power values and of quantitative clinical scores of depressive conditions has been carried out in dynamics of treatment in 40 patients with endogenous depression with the main goal to study neurophysiologic correlates and to search possible predictors of therapeutic outcome. The reduction of depressive symptoms by the end of the treatment course was associated with EEG signs of improvement of brain functional state. Significant correlations have been revealed between the EEG narrow-band spectral power values and clinical scores. As well, significant correlations have been revealed between some initial (before beginning of treatment) EEG parameters and quantitative clinical scores at the stage of remission establishing. The values of EEG beta-1 and beta-2 spectral power appeared to be such predictors, while initially larger values of EEG beta activity spectral power were associated with higher pronounce of residual depressive symptoms after the treatment course. The data obtained allow to justify basic views on brain mechanisms of various aspects of depressive disorders, and to reveal possible neurophysiological predictors of efficacy of treatment of endogenous depression.
对40例内源性抑郁症患者治疗过程中的脑电图频谱功率值和抑郁状况的定量临床评分进行了动态分析，主要目的是研究神经生理相关性并寻找治疗结果的可能预测指标。治疗疗程结束时抑郁症状的减轻与脑功能状态改善的脑电图征象相关。脑电图窄带频谱功率值与临床评分之间存在显著相关性。此外，在缓解期建立阶段，一些初始（治疗开始前）脑电图参数与定量临床评分之间也存在显著相关性。脑电图β-1和β-2频谱功率值似乎就是这样的预测指标，而最初较大的脑电图β活动频谱功率值与治疗疗程后残留抑郁症状的较高程度相关。所获得的数据有助于证明关于抑郁症各方面脑机制的基本观点，并揭示内源性抑郁症治疗效果的可能神经生理预测指标。
