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高 科技 成像在早期乳腺癌监测中的应用。

Use of high technology imaging for surveillance of early stage breast cancer.

机构信息

Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, 307 East 63rd Street, 3rd Floor, New York, NY 10021, USA.

出版信息

Breast Cancer Res Treat. 2012 Jan;131(2):663-70. doi: 10.1007/s10549-011-1773-y. Epub 2011 Sep 24.

Abstract

Guidelines do not support utilization of high technology radiologic imaging (HTRI) for surveillance after curative treatment for early stage breast cancer. Surveillance, Epidemiology, and End Results (SEER)-Medicare linked data were used to identify 25,555 women diagnosed with stage I-II breast cancer between 1998 and 2003 who survived ≥ 48 months from diagnosis without evidence of second primary or recurrent cancer in this interval. HTRI utilization (computerized tomography scanning (CT), bone scan (BS), breast magnetic resonance imaging, and positron emission tomography scans) was measured in months 13-48 post-diagnosis. Cases were individually matched to 75,669 female Medicare enrollees without cancer. Factors associated with HTRI utilization were evaluated. Forty percent of women with stage I-II breast cancer and 25% of controls had ≥ 1 HTRI during the surveillance interval (P < 0.001). High utilization rates were observed for CT (30%) and BSs (19%). The proportion of women who had a CT during the surveillance period increased in both cancer survivors and controls. Among breast cancer cases age <80, higher comorbidity index, stage II disease, and more recent diagnosis were independently associated with receipt of HTRI. Paralleling patterns observed in controls, HTRI utilization for surveillance following diagnosis of early stage breast cancer has steadily increased among Medicare beneficiaries. Strategies to foster judicious utilization of HTRI should be a priority.

摘要

指南不支持在早期乳腺癌治愈性治疗后利用高科技放射影像学(HTRI)进行监测。使用监测、流行病学和最终结果(SEER)-医疗保险链接数据,确定了 1998 年至 2003 年间诊断为 I 期至 II 期乳腺癌且在无第二原发或复发癌证据的情况下存活时间≥48 个月的 25555 名女性。在诊断后 13-48 个月期间测量了 HTRI 的利用情况(计算机断层扫描(CT)、骨扫描(BS)、乳房磁共振成像和正电子发射断层扫描)。将病例与 75669 名无癌症的女性医疗保险参保者进行个体匹配。评估了与 HTRI 利用相关的因素。I 期至 II 期乳腺癌女性中有 40%和对照组中有 25%的女性在监测期间有≥1 次 HTRI(P<0.001)。观察到 CT(30%)和 BS(19%)的高利用率。在癌症幸存者和对照组中,接受 CT 检查的女性比例均有所增加。在年龄<80 岁的乳腺癌病例中,更高的合并症指数、II 期疾病和更近期的诊断与接受 HTRI 治疗独立相关。与对照组中观察到的模式相似,早期乳腺癌诊断后 HTRI 用于监测的利用率在医疗保险受益人中稳步增加。应优先制定策略,以促进 HTRI 的合理利用。

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