Department of Pharmacology and Experimental Neuroscience, University of Nebraska Medical Center, Omaha, NE, USA.
J Neuroimmune Pharmacol. 2012 Mar;7(1):95-112. doi: 10.1007/s11481-011-9315-2. Epub 2011 Sep 24.
The growing family of interleukin (IL)-12-like cytokines produced by activated macrophages and dendritic cells became the important players in the control of infections, development of inflammation, autoimmunity and cancer. However, the role of one of them-heterodimer IL-23, which consists of IL12p40 and the unique p19 subunit in HIV-1 infection pathogenesis and progression to AIDS, represent special interest. We overviewed findings of IL-23 involvement in control of peripheral bacterial pathogens and opportunistic infection, central nervous system (CNS) viral infections and autoimmune disorders, and tumorogenesis, which potentially could be applicable to HIV-1 and AIDS.
由活化的巨噬细胞和树突状细胞产生的白细胞介素（IL）-12 样细胞因子家族不断扩大，成为控制感染、炎症发展、自身免疫和癌症的重要参与者。然而，其中一种细胞因子——异二聚体 IL-23，由 IL12p40 和 HIV-1 感染发病机制和艾滋病进展中的独特 p19 亚单位组成，其作用代表了特殊的兴趣。我们综述了 IL-23 参与控制外周细菌病原体和机会性感染、中枢神经系统（CNS）病毒感染和自身免疫性疾病以及肿瘤发生的研究结果，这些结果可能适用于 HIV-1 和艾滋病。
