School for Public Health and Primary Care, Department of Health Promotion, Maastricht University, P.O. Box 616, Maastricht 6200, The Netherlands.
Tob Control. 2012 May;21(3):347-54. doi: 10.1136/tc.2011.042739. Epub 2011 Sep 26.
To examine whether genetic testing for smoking-related diseases benefits smoking cessation.
PubMed, EMBASE, ERIC, PsycINFO, PsychArticles, CiNAHL and socINDEX databases, the search engine Google Scholar, and key-author and reference list searches. Study selection Randomised controlled smoking cessation interventions using genetic testing for smoking-related diseases.
Consistent with the Cochrane guidelines, two reviewers completed the review process (initial n=139) in three phases, title selection (n=56), abstract selection (n=28) and whole paper selection (n=9). From these nine studies, each reviewer extracted information about outcome measures and statistical and methodological quality. Data synthesis Relevant data were abstracted from included papers and were subsequently subjected to meta-analysis.
Interest in genetic testing was relatively high with 60-80% of smokers reporting to be interested. The authors observed positive short-term effects on risk perception, motivation to quit smoking and smoking cessation, but these effects fade at longer follow-ups. Importantly, the authors did not find any evidence of adverse effect of testing negative on the risk-predisposing gene.
This systematic review does not provide solid evidence for the proposed beneficial effects of genetic testing for smoking-related diseases on smoking cessation, but does suggest the presence of an immediate motivational effect, such that genetic testing resulted in higher risk perception and more motivation to quit smoking.
研究针对与吸烟相关疾病的基因检测是否有益于戒烟。
PubMed、EMBASE、ERIC、PsycINFO、PsychArticles、CiNAHL 和 socINDEX 数据库、搜索引擎 Google Scholar 以及主要作者和参考文献检索。
使用与吸烟相关疾病的基因检测进行随机对照戒烟干预的研究。
两名评审员按照 Cochrane 指南，分三个阶段完成了评审过程（初始 n=139），包括标题选择（n=56）、摘要选择（n=28）和全文选择（n=9）。从这 9 项研究中，每位评审员提取了关于结局测量和统计方法学质量的信息。
从纳入的论文中摘录相关数据，并进行荟萃分析。
对基因检测的兴趣相对较高，有 60-80%的吸烟者表示有兴趣。作者观察到对风险感知、戒烟动机和戒烟的短期积极影响，但这些影响在较长的随访中消失。重要的是，作者没有发现基因检测呈阴性对风险易感基因产生不利影响的任何证据。
本系统评价并未为针对与吸烟相关疾病的基因检测对戒烟的拟议有益效果提供确凿证据，但确实表明存在即时的激励效应，即基因检测导致更高的风险感知和更强的戒烟动机。
