Pham Ba', Stern Anita, Chen Wendong, Sander Beate, John-Baptiste Ava, Thein Hla-Hla, Gomes Tara, Wodchis Walter P, Bayoumi Ahmed, Machado Márcio, Carcone Steven, Krahn Murray
TorontoHealth Economics and Technology Assessment Collaborative,Department of Health Policy Management andEvaluation, University of Toronto, 144 College Street, Toronto, Ontario, Canada.
Arch Intern Med. 2011 Nov 14;171(20):1839-47. doi: 10.1001/archinternmed.2011.473. Epub 2011 Sep 26.
Pressure ulcers are common in many care settings, with adverse health outcomes and high treatment costs. We evaluated the cost-effectiveness of evidence-based strategies to improve current prevention practice in long-term care facilities.
We used a validated Markov model to compare current prevention practice with the following 4 quality improvement strategies: (1) pressure redistribution mattresses for all residents, (2) oral nutritional supplements for high-risk residents with recent weight loss, (3) skin emollients for high-risk residents with dry skin, and (4) foam cleansing for high-risk residents requiring incontinence care. Primary outcomes included lifetime risk of stage 2 to 4 pressure ulcers, quality-adjusted life-years (QALYs), and lifetime costs, calculated according to a single health care payer's perspective and expressed in 2009 Canadian dollars (Can$1 = US$0.84).
Strategies cost on average $11.66 per resident per week. They reduced lifetime risk; the associated number needed to treat was 45 (strategy 1), 63 (strategy 4), 158 (strategy 3), and 333 (strategy 2). Strategy 1 and 4 minimally improved QALYs and reduced the mean lifetime cost by $115 and $179 per resident, respectively. The cost per QALY gained was approximately $78 000 for strategy 3 and $7.8 million for strategy 2. If decision makers are willing to pay up to $50 000 for 1 QALY gained, the probability that improving prevention is cost-effective is 94% (strategy 4), 82% (strategy 1), 43% (strategy 3), and 1% (strategy 2).
The clinical and economic evidence supports pressure redistribution mattresses for all long-term care residents. Improving prevention with perineal foam cleansers and dry skin emollients appears to be cost-effective, but firm conclusions are limited by the available clinical evidence.
压疮在许多护理环境中都很常见,会带来不良健康后果且治疗成本高昂。我们评估了基于证据的策略在长期护理机构中改善当前预防措施的成本效益。
我们使用经过验证的马尔可夫模型,将当前的预防措施与以下4种质量改进策略进行比较:(1)为所有居民使用压力重新分布床垫;(2)为近期体重减轻的高危居民提供口服营养补充剂;(3)为皮肤干燥的高危居民使用皮肤润肤剂;(4)为需要失禁护理的高危居民使用泡沫清洁剂。主要结局包括2至4期压疮的终生风险、质量调整生命年(QALY)和终生成本,这些是根据单一医疗保健支付者的视角计算得出的,并以2009年加拿大元表示(1加元 = 0.84美元)。
这些策略平均每位居民每周花费11.66加元。它们降低了终生风险;相关的治疗所需人数分别为45(策略1)、63(策略4)、158(策略3)和333(策略2)。策略1和4对QALY的改善微乎其微,每位居民的平均终生成本分别降低了115加元和179加元。策略3每获得1个QALY的成本约为78000加元,策略2则为780万加元。如果决策者愿意为获得1个QALY支付高达50000加元,那么改善预防措施具有成本效益的概率分别为94%(策略4)、82%(策略1)、43%(策略3)和1%(策略2)。
临床和经济证据支持为所有长期护理居民使用压力重新分布床垫。使用会阴泡沫清洁剂和干性皮肤润肤剂来改善预防措施似乎具有成本效益,但确切结论受到现有临床证据的限制。