Instituto de Neurociencias de Alicante, Universidad Miguel Hernández-CSIC Alacant, Spain.
Front Mol Neurosci. 2011 Sep 13;4:22. doi: 10.3389/fnmol.2011.00022. eCollection 2011.
A common feature in the Alzheimer's disease (AD) brain is the presence of acetylcholinesterase (AChE) which is commonly associated with β-amyloid plaques and neurofibrillary tangles (NFT). Although our understanding of the relationship between AChE and the pathological features of AD is incomplete, increasing evidence suggests that both β-amyloid protein (Aβ) and abnormally hyperphosphorylated tau (P-tau) can influence AChE expression. We also review recent findings which suggest the possible role of AChE in the development of a vicious cycle of Aβ and P-tau dysregulation and discuss the limited and temporary effect of therapeutic intervention with AChE inhibitors.
阿尔茨海默病（AD）大脑的一个共同特征是存在乙酰胆碱酯酶（AChE），它通常与β-淀粉样斑块和神经原纤维缠结（NFT）有关。尽管我们对 AChE 与 AD 病理特征之间的关系了解不完整，但越来越多的证据表明，β-淀粉样蛋白（Aβ）和异常过度磷酸化的 tau（P-tau）都可以影响 AChE 的表达。我们还回顾了最近的发现，这些发现表明 AChE 在 Aβ和 P-tau 失调的恶性循环发展中可能发挥作用，并讨论了 AChE 抑制剂治疗干预的有限和暂时效果。
