Arai S, Hayashi S
Pharma Research Laboratories, Hoechst Japan Limited, Saitama.
Infection. 1990 May-Jun;18(3):186-90. doi: 10.1007/BF01642112.
The therapeutic effects of cefpirome (HR 810), a new cephalosporin, on mixed infections induced in mice with Enterococcus faecalis HL1147 and Escherichia coli HL34 were compared with those of ampicillin (AMP), cefuzonam (CZON), and ceftazidime (CAZ). Cefpirome was more effective in protecting mice with systemic mixed infection (median effective dose, 52 mg/kg) than the other antibiotics (all more than 320 mg/kg). With increasing doses of cefpirome, the percentages of the animals having E. faecalis and E. coli bacteremia were decreased. CZON and CAZ reduced only E. coli, and AMP failed to reduce both strains. In the mice with urinary tract mixed infection, cefpirome and CZON (40 mg/kg x 5, s.c.) significantly decreased the cfu/g kidney (p less than 0.01 vs. nontreated control), while AMP and CAZ were active only against E. faecalis (p less than 0.05) and E. coli (p less than 0.01), respectively.
将新型头孢菌素头孢匹罗（HR 810）对粪肠球菌HL1147和大肠杆菌HL34诱导的小鼠混合感染的治疗效果，与氨苄西林（AMP）、头孢唑南（CZON）和头孢他啶（CAZ）进行了比较。头孢匹罗在保护全身性混合感染小鼠方面（半数有效剂量为52mg/kg）比其他抗生素（均超过320mg/kg）更有效。随着头孢匹罗剂量增加，发生粪肠球菌和大肠杆菌菌血症的动物百分比降低。头孢唑南和头孢他啶仅减少大肠杆菌，而氨苄西林对两种菌株均无减少作用。在患有泌尿系统混合感染的小鼠中，头孢匹罗和头孢唑南（40mg/kg×5，皮下注射）显著降低了肾脏中的菌落形成单位/克（与未治疗对照组相比，p<0.01），而氨苄西林和头孢他啶分别仅对粪肠球菌（p<0.05）和大肠杆菌（p<0.01）有活性。
