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新型头孢菌素HR 810与其他五种头孢菌素及两种氨基糖苷类药物相比的体外抗菌活性及β-内酰胺酶稳定性

The Antibacterial activity in vitro and beta-lactamase stability of the new cephalosporin HR 810 in comparison with five other cephalosporins and two aminoglycosides.

作者信息

Seibert G, Limbert M, Winkler I, Dick T

出版信息

Infection. 1983 Sep-Oct;11(5):275-9. doi: 10.1007/BF01641262.

DOI:10.1007/BF01641262
PMID:6315595
Abstract

The antibacterial activity of the cephalosporin antibiotic HR 810 was evaluated in comparison with cefoperazone, cefotaxime, ceftazidime, ceftriaxone, latamoxef, gentamicin and amikacin against 1500 clinical isolates. HR 810 is the antibiotic with the broadest antimicrobial spectrum. It is also highly active against isolates of the genera Pseudomonas, Enterobacter, Staphylococcus and enterococci. HR 810 is very stable against hydrolysis by plasmid-coded and chromosomally coded beta-lactamases.

摘要

将头孢菌素抗生素HR 810与头孢哌酮、头孢噻肟、头孢他啶、头孢曲松、拉氧头孢、庆大霉素和阿米卡星进行比较，评估了其对1500株临床分离菌的抗菌活性。HR 810是抗菌谱最广的抗生素。它对假单胞菌属、肠杆菌属、葡萄球菌属和肠球菌属的分离菌也具有高活性。HR 810对质粒编码和染色体编码的β-内酰胺酶的水解作用非常稳定。

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本文引用的文献

1
Comparative activities of 13 beta-lactam antibiotics.13种β-内酰胺类抗生素的比较活性
Antimicrob Agents Chemother. 1982 Jun;21(6):925-34. doi: 10.1128/AAC.21.6.925.
2
HR 810, a new parenteral cephalosporin with a broad antibacterial spectrum.HR 810，一种新型的具有广谱抗菌活性的肠胃外使用的头孢菌素。
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The in vitro activity, human pharmacology, and clinical effectiveness of new beta-lactam antibiotics.新型β-内酰胺类抗生素的体外活性、人体药理学及临床疗效
在常见大肠杆菌宿主背景中表达的β-内酰胺酶检测板的开发，用于评估新型β-内酰胺类抗生素。
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Antimicrobial activities of BMY-28142, cefbuperazone, and cefpiramide compared with those of other cephalosporins.将BMY-28142、头孢布宗和头孢匹胺的抗菌活性与其他头孢菌素的抗菌活性进行比较。
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Disk diffusion testing, quality control guidelines, and antimicrobial spectrum of HR810, a fourth-generation cephalosporin, in clinical microbiology laboratories.临床微生物实验室中第四代头孢菌素HR810的纸片扩散法检测、质量控制指南及抗菌谱
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Chemotherapeutic properties of the new cephalosporin antibiotic HR810 in laboratory animals.新型头孢菌素抗生素HR810在实验动物中的化疗特性
Infection. 1984 Jul-Aug;12(4):286-92. doi: 10.1007/BF01645963.
9
Antimicrobial activity of HR810 against 419 strict anaerobic bacteria.HR810对419株严格厌氧菌的抗菌活性。
Antimicrob Agents Chemother. 1985 Mar;27(3):413-5. doi: 10.1128/AAC.27.3.413.
10
The in vitro activity and beta-lactamase stability of cefpirome (HR 810), a pyridine cephalosporin agent active against staphylococci, Enterobacteriaceae and Pseudomonas aeruginosa.头孢匹罗（HR 810）是一种对葡萄球菌、肠杆菌科细菌和铜绿假单胞菌有效的吡啶头孢菌素类药物，其体外活性及对β-内酰胺酶的稳定性。
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Annu Rev Pharmacol Toxicol. 1982;22:599-642. doi: 10.1146/annurev.pa.22.040182.003123.
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Infection. 1977;5(1):9-12. doi: 10.1007/BF01639102.