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[小鼠天然及辐射后挥发性分泌物对受辐照动物免疫反应性和血细胞数量的影响]

[Effect of natural and postradiation volatile secretions of mice on the immune reactivity and blood cellularity of irradiated animals].

作者信息

Isaeva V G, Surinov B P

出版信息

Radiats Biol Radioecol. 2011 Jul-Aug;51(4):444-50.

Abstract

It has been shown that natural and postradiation volatile urinary secretions of mice can remotely restore the immune reactivity and blood indices reduced as a result of exposure of laboratory mice to ionizing radiation. Antibody formation in spleen of gamma-irradiated (1 Gy) CBA strain mice was increased after exposure of both syngeneic and allogeneic animals with urine volatile secretions. Volatile natural secretions of intact mice have a more pronounced antibody stimulating activity than volatile secretions from animals exposed to gamma-radiation. Immunoreactivity ofy-irradiated C57B16 strain mice with low olfactory reactivity increases only after their exposure with volatile secretions of intact syngeneic animals. The total number of leukocytes and lymphocytes in the peripheral blood of gamma-irradiated (1 Gy) inbred mice increases after exposure with secretions obtained from them before irradiation. The role of hemo-signalling in the selective stimulation of immunity and blood content in conditions of radiation damage is discussed.

摘要

研究表明,小鼠的天然和辐射后挥发性尿液分泌物能够远程恢复因实验室小鼠暴露于电离辐射而降低的免疫反应性和血液指标。用尿液挥发性分泌物暴露同基因和异基因动物后,γ射线照射(1 Gy)的CBA品系小鼠脾脏中的抗体形成增加。完整小鼠的挥发性天然分泌物比暴露于γ辐射的动物的挥发性分泌物具有更明显的抗体刺激活性。嗅觉反应性低的γ射线照射的C57B16品系小鼠,只有在暴露于完整同基因动物的挥发性分泌物后,其免疫反应性才会增加。γ射线照射(1 Gy)的近交系小鼠在暴露于辐射前从它们身上获得的分泌物后,外周血中白细胞和淋巴细胞的总数增加。讨论了血液信号在辐射损伤条件下对免疫和血液含量的选择性刺激中的作用。

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