Department of Neurology, Mount Sinai School of Medicine, New York, New York 10029, USA.
Ann N Y Acad Sci. 2011 Sep;1233:214-8. doi: 10.1111/j.1749-6632.2011.06176.x.
Sixteen neurons, including vestibular-only (VO), eye-head velocity (EHV), and position-vestibular-pause (PVP) neurons sensitive to head tilt were recorded in the rostromedial and in superior vestibular nuclei. Projection of the otolith polarization vector to the horizontal plane (response vector orientation [RVO]) was determined before and after prolonged head orientation in side-down position. The RVO of VO neurons shifted toward alignment with the axis of gravity when the head was in the position of adaptation. PVP neurons had similar changes in RVO. There were also changes in RVO in some EHV neurons, but generally in directions not related to gravity. Modeling studies have suggested that the tendency to align RVOs with gravity leads to tuning of gravity-dependent angular vestibular ocular reflex (aVOR) gain changes to the position of adaptation. Thus, coding of orientation in PVP neurons would contribute significantly to the gravity-dependent adaptation of the aVOR.
在中脑前庭核和上前庭核中记录了 16 个神经元，包括仅对前庭敏感的神经元（VO）、眼头速度（EHV）和位置前庭暂停（PVP）神经元，它们对头部倾斜敏感。在头向侧面倾斜的位置长时间倾斜后，确定了耳石极化矢量在水平面上的投影（响应矢量方向[RVO]）。当头处于适应位置时，VO 神经元的 RVO 向与重力轴对齐的方向移动。PVP 神经元的 RVO 也发生了类似的变化。一些 EHV 神经元的 RVO 也发生了变化，但通常与重力无关。模型研究表明，RVO 与重力对齐的趋势导致与重力相关的角前庭眼反射（aVOR）增益变化的调谐适应位置。因此，PVP 神经元的方向编码将对 aVOR 的与重力相关的适应做出重要贡献。
