Department of Pathology, Seoul National University Hospital Department of Pathology, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, Seoul, Korea.
Pathol Int. 2011 Oct;61(10):593-7. doi: 10.1111/j.1440-1827.2011.02707.x. Epub 2011 Aug 4.
Tumor-to-tumor metastasis is a rare, but well-recognized phenomenon. Here, we report a unique case of hepatocellular carcinoma (HCC) metastatic to parathyroid adenoma. A 53-year-old-man with a history of HCC presented with hypercalcemia. It was found that he also had hyperparathyroidism with a hypoechoic mass in the lower portion of the right thyroid gland area. The patient underwent parathyroidectomy, and a mass measuring 1.5 × 1.0 cm was detected. Microscopic and immunohistochemical examination disclosed parathyroid adenoma with a focus of metastatic HCC. For the patient, it was the only distant metastasis revealed until the last follow-up. To the best of our knowledge, this is the first reported case of tumor-to-tumor metastasis in which HCC is the donor.
肿瘤对肿瘤转移是一种罕见但已被认识的现象。在这里，我们报告了一个独特的肝细胞癌（HCC）转移到甲状旁腺瘤的病例。一名 53 岁男性，有 HCC 病史，表现为高钙血症。发现他还患有甲状旁腺功能亢进症，右甲状腺区下部有低回声肿块。患者接受了甲状旁腺切除术，发现一个 1.5×1.0cm 的肿块。显微镜和免疫组织化学检查显示甲状旁腺腺瘤伴 HCC 转移灶。对于该患者，这是直到最后一次随访时唯一发现的远处转移。据我们所知，这是首例报道的 HCC 作为供体的肿瘤对肿瘤转移病例。
