College of Bioresource Sciences, Nihon University, Fujisawa, Japan.
Anim Sci J. 2011 Oct;82(5):713-6. doi: 10.1111/j.1740-0929.2011.00938.x. Epub 2011 Aug 16.
We determined the sequence of the immunoglobulin gamma heavy-chain constant (IGHC) region of the Mongolian gerbil (Meriones unguiculatus). To isolate a part of the IGHC complementary DNA, we designed primers on the basis of highly conserved sequences in mouse, rat and hamster. The deduced IGHC is structurally similar to counterparts in other mammalian species and shows 84.6% identity to the IGHC of hamster IgG, 76.6% to rat IgG1, 83.3% to rat IgG2a, 78.1% to mouse IgG1, 81.8% to mouse IgG2a, 79.1% to mouse IgG2b and 79.2% to mouse IgG3 at the nucleotide level. The results suggest that gerbil IgG is closely related to hamster IgG and rat IgG2a.
我们测定了蒙古沙鼠（Meriones unguiculatus）免疫球蛋白γ重链恒定区（IGHC）的序列。为了分离 IGHC 的互补 DNA 部分，我们根据小鼠、大鼠和仓鼠中高度保守的序列设计了引物。推断出的 IGHC 在结构上与其他哺乳动物物种的 IGHC 相似，与仓鼠 IgG 的 IGHC 具有 84.6%的同一性，与大鼠 IgG1 具有 76.6%的同一性，与大鼠 IgG2a 具有 83.3%的同一性，与小鼠 IgG1 具有 78.1%的同一性，与小鼠 IgG2a 具有 81.8%的同一性，与小鼠 IgG2b 具有 79.1%的同一性，与小鼠 IgG3 具有 79.2%的同一性。结果表明，沙鼠 IgG 与仓鼠 IgG 和大鼠 IgG2a 密切相关。
