口服铁螯合剂地拉罗司通过靶向半胱天冬酶诱导髓系白血病细胞凋亡。 - Suppr

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超能文献

The oral iron chelator deferasirox induces apoptosis in myeloid leukemia cells by targeting caspase.

作者信息

Kim Jung-Lim, Kang Han-Na, Kang Myoung Hee, Yoo Young A, Kim Jun Suk, Choi Chul Won

机构信息

Graduate School of Medicine, Korea University College of Medicine, Seoul, South Korea.

出版信息

Acta Haematol. 2011;126(4):241-5. doi: 10.1159/000330608. Epub 2011 Sep 27.

DOI:10.1159/000330608

PMID:21951998

Abstract

摘要

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The oral iron chelator deferasirox induces apoptosis in myeloid leukemia cells by targeting caspase.口服铁螯合剂地拉罗司通过靶向半胱天冬酶诱导髓系白血病细胞凋亡。

Acta Haematol. 2011;126(4):241-5. doi: 10.1159/000330608. Epub 2011 Sep 27.

The iron chelator, deferasirox, as a novel strategy for cancer treatment: oral activity against human lung tumor xenografts and molecular mechanism of action.铁螯合剂地拉罗司作为一种治疗癌症的新策略：口服活性对人肺癌异种移植物的作用及其作用机制。

Mol Pharmacol. 2013 Jan;83(1):179-90. doi: 10.1124/mol.112.081893. Epub 2012 Oct 16.

Deferasirox (ICL670A) effectively inhibits oesophageal cancer growth in vitro and in vivo.地拉罗司（ICL670A）能有效抑制食管癌细胞的体外和体内生长。

Br J Pharmacol. 2013 Mar;168(6):1316-28. doi: 10.1111/bph.12045.

Deferasirox shows in vitro and in vivo antileukemic effects on murine leukemic cell lines regardless of iron status.地拉罗司在体外和体内对无论铁状态如何的小鼠白血病细胞系均显示出抗白血病作用。

Exp Hematol. 2013 Jun;41(6):539-46. doi: 10.1016/j.exphem.2013.02.004. Epub 2013 Feb 13.

The oral iron chelator deferasirox represses signaling through the mTOR in myeloid leukemia cells by enhancing expression of REDD1.口服铁螯合剂地拉罗司通过增强REDD1的表达来抑制髓系白血病细胞中mTOR信号通路。

Cancer Sci. 2009 May;100(5):970-7. doi: 10.1111/j.1349-7006.2009.01131.x. Epub 2009 Mar 9.

Deferasirox, a novel oral iron chelator, shows antiproliferative activity against pancreatic cancer in vitro and in vivo.地拉罗司，一种新型口服铁螯合剂，在体外和体内均显示出对胰腺癌的抗增殖活性。

BMC Cancer. 2016 Aug 31;16(1):702. doi: 10.1186/s12885-016-2744-9.

Differential apoptosis-inducing effect of quercetin and its glycosides in human promyeloleukemic HL-60 cells by alternative activation of the caspase 3 cascade.槲皮素及其糖苷通过半胱天冬酶3级联反应的交替激活对人早幼粒白血病HL-60细胞产生不同的凋亡诱导作用。

J Cell Biochem. 2003 Aug 1;89(5):1044-55. doi: 10.1002/jcb.10559.

Antiproliferation effects of ponicidin on human myeloid leukemia cells in vitro.ponicidin对人髓系白血病细胞的体外抗增殖作用。

Oncol Rep. 2005 Apr;13(4):653-7.

Iron-induced cardiac damage: role of apoptosis and deferasirox intervention.铁诱导的心脏损伤：细胞凋亡的作用与地拉罗司干预

J Pharmacol Exp Ther. 2011 Jan;336(1):56-63. doi: 10.1124/jpet.110.172668. Epub 2010 Oct 14.

Deferasirox--an oral agent for chronic iron overload.地拉罗司——一种用于慢性铁过载的口服药物。

Ann Pharmacother. 2006 Jun;40(6):1110-7. doi: 10.1345/aph.1G566. Epub 2006 May 30.

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Iron Chelator Induces Apoptosis in Osteosarcoma Cells by Disrupting Intracellular Iron Homeostasis and Activating the MAPK Pathway.铁螯合剂通过破坏细胞内铁稳态和激活 MAPK 通路诱导骨肉瘤细胞凋亡。

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Antioxidants (Basel). 2020 Dec 1;9(12):1212. doi: 10.3390/antiox9121212.

Effects of Deferoxamine on Leukemia In Vitro and Its Related Mechanism.去铁胺对白血病的体外作用及其相关机制。

Med Sci Monit. 2018 Sep 24;24:6735-6741. doi: 10.12659/MSM.910325.

Use of deferasirox, an iron chelator, to overcome imatinib resistance of chronic myeloid leukemia cells.使用铁螯合剂地拉罗司克服慢性髓性白血病细胞对伊马替尼的耐药性。

Korean J Intern Med. 2016 Mar;31(2):357-66. doi: 10.3904/kjim.2015.024. Epub 2016 Feb 15.

Low oxygen tension reverses antineoplastic effect of iron chelator deferasirox in human glioblastoma cells.低氧张力可逆转铁螯合剂地拉罗司对人胶质母细胞瘤细胞的抗肿瘤作用。

BMC Cancer. 2016 Feb 1;16:51. doi: 10.1186/s12885-016-2074-y.

Iron chelator-induced apoptosis via the ER stress pathway in gastric cancer cells.铁螯合剂通过内质网应激途径诱导胃癌细胞凋亡。

Tumour Biol. 2016 Jul;37(7):9709-19. doi: 10.1007/s13277-016-4878-4. Epub 2016 Jan 23.

Acute Liver Failure in a Pediatric Patient with Congenital Dysery-Thropoietic Anemia Type I Treated with Deferasirox.一名患有I型先天性异常红细胞生成性贫血的儿科患者使用地拉罗司治疗后出现急性肝衰竭

Hematol Rep. 2015 Sep 23;7(3):5987. doi: 10.4081/hr.2015.5987.

Anti-leukemic properties of deferasirox via apoptosis in murine leukemia cell lines.地拉罗司通过诱导小鼠白血病细胞系凋亡发挥抗白血病特性。

Blood Res. 2015 Mar;50(1):33-9. doi: 10.5045/br.2015.50.1.33. Epub 2015 Mar 24.

Effects of iron depletion on CALM-AF10 leukemias.铁缺乏对CALM-AF10白血病的影响。

Exp Hematol. 2014 Dec;42(12):1022-1030.e1. doi: 10.1016/j.exphem.2014.08.004. Epub 2014 Sep 3.

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