Department of Dermatology, University Hospital Erlangen, Germany.
Cancer J. 2011 Sep-Oct;17(5):337-42. doi: 10.1097/PPO.0b013e3182350077.
Dendritic cells (DCs) control the initiation and differentiation of T cells. In the steady state, DCs mediate tolerance. To achieve immunization, the tolerogenic function of DCs must be switched off by inducing their maturation with appropriate "adjuvants." Dendritic cells form a system composed of distinct subsets that differ in their expression of endocytic and signaling receptors. These subsets have different capacities to differentiate and polarize T cells and to cross-present antigen to expand CD8+ T cells. Optimization of vaccines is possible by exploiting the unique biological properties of DCs.
树突状细胞（DCs）控制 T 细胞的启动和分化。在稳态下，DCs介导耐受。为了实现免疫，必须通过用适当的“佐剂”诱导其成熟来关闭 DCs 的耐受功能。树突状细胞形成了一个由不同亚群组成的系统，这些亚群在摄取和信号受体的表达上存在差异。这些亚群具有不同的分化和极化 T 细胞以及交叉呈递抗原以扩增 CD8+T 细胞的能力。通过利用 DCs 的独特生物学特性，可以优化疫苗。
