[撒哈拉以南非洲地区恶性疟原虫的化学敏感性：法国武装部队卫生服务热带医学研究所两年半研究评估]
[Chemosensibility of Plasmodium falciparum in Africa south of the Sahara: evaluation of two and a half years' research at the Tropical Medicine Institute of the Health Service of the French Armed Forces].
作者信息
Spiegel A, Doury J C, Daumerie D, Baudon D
机构信息
Service de Médecine des Collectivités, Institut de Médecine Tropicale du Service de Santé des Armées, Marseille.
出版信息
Med Trop (Mars). 1990 Jan-Mar;50(1):17-20.
PMID:2195281
Abstract
From March 1987 to June 1989, 194 isolates of Plasmodium falciparum were studied in vitro by the isotopic semi-microtest. 86.1% were resistant to chloroquine; 9.5% had a decrease of sensibility to quinine and 3.3% a decrease of sensibility to mefloquine. There was a positive correlation between I.C. 50 of the antimalarial drugs compared by pairs.
摘要
1987年3月至1989年6月，采用同位素半微量试验对194株恶性疟原虫进行了体外研究。86.1%的菌株对氯喹耐药；9.5%对奎宁敏感性降低，3.3%对甲氟喹敏感性降低。成对比较的抗疟药物的半数抑制浓度（IC50）之间存在正相关。
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