Simooya O O, Aderounmu A F, Salako L A
Department of Pharmacology and Therapeutics, University of Ibadan, Nigeria.
Afr J Med Med Sci. 1988 Mar;17(1):3-7.
The schizontocidal effect of chloroquine was compared to that of amodiaquine in vivo and mefloquine in vitro. In the in-vivo study, 32 patients were randomly given chloroquine whilst 29 received amodiaquine. The mean parasite clearance time was 2.5 days for chloroquine and 2.4 days for amodiaquine. These times were not significantly different. The cure rate in both groups up to day 14 was 100%. In the in-vitro study, three isolates of Plasmodium falciparum were compared for their sensitivity to chloroquine and mefloquine. In all three isolates schizogony was inhibited at a concentration of 0.8 x 10(-6) mol/l of either drug. It was concluded that chloroquine is still an effective schizontocide and should remain the drug of choice for the treatment of P. falciparum in the Ibadan area.
在体内将氯喹的裂殖体杀灭作用与氨酚喹进行了比较，在体外将其与甲氟喹进行了比较。在体内研究中，32例患者被随机给予氯喹，而29例接受了氨酚喹。氯喹的平均寄生虫清除时间为2.5天，氨酚喹为2.4天。这些时间没有显著差异。至第14天两组的治愈率均为100%。在体外研究中，比较了三株恶性疟原虫分离株对氯喹和甲氟喹的敏感性。在所有三株分离株中，两种药物在浓度为0.8×10(-6)mol/l时均能抑制裂体增殖。得出的结论是，氯喹仍然是一种有效的裂殖体杀灭剂，应仍然是伊巴丹地区治疗恶性疟原虫的首选药物。
