肾脏 Notch 结构：发育与疾病。
Notch in the kidney: development and disease.
机构信息
Department of Nephrology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
出版信息
J Pathol. 2012 Jan;226(2):394-403. doi: 10.1002/path.2967. Epub 2011 Aug 24.
Abstract
Notch signalling is a highly conserved cell-cell communication mechanism that regulates development, tissue homeostasis, and repair. Within the kidney, Notch has an important function in orchestrating kidney development. Recent studies indicate that Notch plays a key role in establishing proximal epithelial fate during nephron segmentation as well as the differentiation of principal cells in the renal collecting system. Notch signalling is markedly reduced in the adult kidney; however, increased Notch signalling has been noted in both acute and chronic kidney injury. Increased glomerular epithelial Notch signalling has been associated with albuminuria and glomerulosclerosis, while tubular epithelial Notch activation caused fibrosis development most likely inducing an improper epithelial repair pathway. Recent studies thereby indicate that Notch is a key regulator of kidney development, repair, and injury.
摘要
Notch 信号通路是一种高度保守的细胞间通讯机制，它调节着发育、组织稳态和修复。在肾脏中，Notch 在协调肾脏发育方面具有重要作用。最近的研究表明，Notch 在肾单位分割过程中建立近端上皮命运以及肾集合系统主要细胞的分化中起着关键作用。Notch 信号在成人肾脏中显著降低；然而，在急性和慢性肾损伤中，Notch 信号增加。肾小球上皮 Notch 信号增加与白蛋白尿和肾小球硬化有关，而肾小管上皮 Notch 激活导致纤维化发展，很可能诱导了一种不当的上皮修复途径。最近的研究表明，Notch 是肾脏发育、修复和损伤的关键调节因子。
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Nat Rev Cancer. 2011 May;11(5):338-51. doi: 10.1038/nrc3035. Epub 2011 Apr 14.
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Expression of Notch1 to -4 and their ligands in renal cell carcinoma: a tissue microarray study.Notch1 至 Notch4 的表达及其配体在肾细胞癌中的研究：组织微阵列分析。
Cancer Genomics Proteomics. 2011 Mar-Apr;8(2):93-101.
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Nephron progenitors in the metanephric mesenchyme.后肾原基在中肾间充质中。
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The fate of Notch-deficient nephrogenic progenitor cells during metanephric kidney development.Notch 缺陷性肾祖细胞在肾原基期肾脏发育中的命运。
Kidney Int. 2011 May;79(10):1099-112. doi: 10.1038/ki.2010.553. Epub 2011 Jan 26.
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The story of Notch and chronic kidney disease.Notch 与慢性肾脏病的故事。
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Epithelial Notch signaling regulates interstitial fibrosis development in the kidneys of mice and humans.上皮 Notch 信号通路调控小鼠和人类肾脏间质纤维化的发展。
J Clin Invest. 2010 Nov;120(11):4040-54. doi: 10.1172/JCI43025. Epub 2010 Oct 18.
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BJU Int. 2011 Feb;107(3):416-24. doi: 10.1111/j.1464-410X.2010.09569.x. Epub 2010 Aug 27.
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