Núcleo de Estudos em Saúde Pública e Envelhecimento, Fundação Oswaldo Cruz/Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Cad Saude Publica. 2011;27 Suppl 3:S345-50. doi: 10.1590/s0102-311x2011001500004.
Few population-based studies have examined long term cognitive trajectory, and these studies were conducted in high income countries. We investigated the association of age, gender and education with 10-year cognitive trajectory in a well-defined population of elderly using data from the Bambuí Cohort Study of Aging, in Brazil. Cognition was measured using the Mini- Mental State Examination (MMSE). Cohort members underwent annual follow-ups. This analysis was based on 12,206 MMSE measurements from 1,461 (91%) baseline participants. We used mixed effects models to study MMSE as outcome. The key findings from this analysis are that women and people with a higher schooling level at baseline had high scores of MMSE, while older participants started off lower. Regarding cognitive decline, women, older people and those with a higher schooling level declined faster.
基于人群的研究很少探讨长期认知轨迹，而且这些研究都是在高收入国家进行的。我们利用巴西班布伊老龄化队列研究的数据，在一个明确界定的老年人群中，调查了年龄、性别和教育程度与 10 年认知轨迹的关系。认知是用简易精神状态检查量表（MMSE）来衡量的。队列成员每年接受一次随访。本分析基于 12206 次 MMSE 测量，来自 1461 名（91%）基线参与者。我们使用混合效应模型来研究 MMSE 作为结果。该分析的主要发现是，女性和基线教育程度较高的人在 MMSE 中得分较高，而年龄较大的参与者起点较低。关于认知能力下降，女性、老年人和教育程度较高的人下降速度较快。
