Núcleo de Estudos em Saúde Pública e Envelhecimento, Fundação Oswaldo Cruz/Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Cad Saude Publica. 2011;27 Suppl 3:S435-43. doi: 10.1590/s0102-311x2011001500014.
This study examined differences in the use of medications in two birth cohorts (born from 1916 to 1926 and from 1927 to 1937) among older elderly in the population-based cohort study in Bambuí, Minas Gerais State, Brazil. The study used data on participants who were 71-81 years of age in the baseline survey in 1997 (n = 492) and in the 11th wave, in 2008 (n = 620). The number of medications currently consumed (mean = 4.6 and 3.4, respectively) and prevalence of polypharmacy (46.6% and 29.1%, respectively) were higher in the more recent cohort as compared to the earlier one. These differences were independent of gender, age, schooling, number of medical visits in the previous 12 months, and number of chronic conditions. The more recent cohort showed significant differences in the use of psychoactive drugs, lipid modifying agents, drugs for diabetes, and antithrombotic agents, as well as changes in drugs used for arterial hypertension. In general, these changes are consistent with those observed in elderly populations in high-income countries.
本研究考察了巴西米纳斯吉拉斯州班布伊人口基础队列研究中两个出生队列（1916 年至 1926 年和 1927 年至 1937 年出生的队列）中高龄老年人用药的差异。该研究使用了 1997 年基线调查中 71-81 岁的参与者的数据（n=492）和第 11 波，即 2008 年的数据（n=620）。与较早的队列相比，最近的队列中当前服用的药物数量（平均值分别为 4.6 和 3.4）和多药治疗的患病率（分别为 46.6%和 29.1%）更高。这些差异与性别、年龄、教育程度、过去 12 个月的医疗就诊次数和慢性病数量无关。最近的队列在使用精神药物、血脂调节剂、糖尿病药物和抗血栓药物方面以及在治疗动脉高血压的药物方面显示出显著差异。总的来说，这些变化与高收入国家老年人群中观察到的变化一致。
