Department of Respiratory Medicine, Hammersmith Hospital, Du Cane Road, London W12 0NN, UK.
Thorax. 2012 Jan;67(1):80-1. doi: 10.1136/thoraxjnl-2011-201027. Epub 2011 Sep 26.
Individuals with pulmonary arteriovenous malformations (PAVMs) and hereditary haemorrhagic telangiectasia (HHT) commonly have low oxygen saturations and anaemia, two parameters generally used to indicate medical fitness to fly. Using a retrospective questionnaire-based study, the authors examined in-flight complications and predictors in 145 HHT patients (96 with PAVMs) who reported 3950 flights, totalling 18 943 flight hours. Dyspnoea and thrombotic complications were less common than expected, and could not be predicted from sea level oxygen saturations or haemoglobin concentrations. Nosebleeds that can bar individuals from boarding a flight occurred in 13.6% (11.5% to 15.8%) of long-haul flights. The findings should influence preflight advice.
患有肺动静脉畸形（PAVMs）和遗传性出血性毛细血管扩张症（HHT）的个体通常存在低氧饱和度和贫血，这两个参数通常用于表明飞行医学适宜性。作者通过回顾性问卷调查研究，调查了 145 名 HHT 患者（96 名患有 PAVMs）在报告的 3950 次飞行中发生的飞行中并发症及其预测因素，总飞行时间为 18943 小时。呼吸困难和血栓并发症比预期的少见，并且不能根据海平面时的氧饱和度或血红蛋白浓度来预测。会导致个人无法登机的鼻出血在长途航班中发生的比例为 13.6%（11.5%至15.8%）。这些发现应该会影响飞行前建议。
