Department of Pharmacy, University of Peshawar, 25120 Pakistan.
Phytother Res. 2012 Apr;26(4):552-6. doi: 10.1002/ptr.3574. Epub 2011 Sep 23.
A study was conducted to identify constituents that might be responsible for analgesic and antiinflammatory conditions. Tasumatrol B, 1,13-diacetyl-10-deacetylbaccatin III (10-DAD) and 4-deacetylbaccatin III (4-DAB) were isolated from the bark extract of Taxus wallichiana Zucc. All the compounds were assessed for analgesic and antiinflammatory activities using an acetic acid-induced writhing model, a hot-plate test, a carrageenan-induced paw oedema model, a cotton-pellet oedema model and in vitro lipoxygenase inhibitory assay. All the compounds, especially tasumatrol B, revealed significant analgesic activity in comparison to a saline group based on an acetic acid-induced model. Similarly all of the test compounds, particularly tasumatrol B, showed significant antiinflammatory activity. However, all the compounds failed to exhibit any considerable activity in of the hot-plate test and the in vitro lipoxygenase inhibitory assay. This study has highlighted the potential of tasumatrol B to be further explored as a new lead compound for the management of pain and inflammation, one that has been discovered by scientific validation of the traditional medicinal use of T. wallichiana Zucc.
一项研究旨在确定可能具有镇痛和抗炎作用的成分。从红豆杉树皮提取物中分离得到了 Tasumatrol B、1,13-二乙酰基-10-去乙酰基紫杉醇（10-DAD）和 4-去乙酰基紫杉醇（4-DAB）。所有化合物均通过乙酸诱导扭体模型、热板试验、角叉菜胶诱导足肿胀模型、棉垫肿胀模型和体外脂氧合酶抑制试验评估其镇痛和抗炎活性。与生理盐水组相比，所有化合物，尤其是 Tasumatrol B，在乙酸诱导模型中均表现出显著的镇痛活性。同样，所有测试化合物，尤其是 Tasumatrol B，表现出显著的抗炎活性。然而，所有化合物在热板试验和体外脂氧合酶抑制试验中均未表现出任何显著的活性。这项研究强调了 Tasumatrol B 作为一种新的先导化合物，具有进一步探索的潜力，可用于治疗疼痛和炎症，这是通过对红豆杉的传统药用用途进行科学验证而发现的。
