Institute of Behavioral Sciences, University of Helsinki, Helsinki, Finland.
Diabetes Care. 2011 Dec;34(12):2545-7. doi: 10.2337/dc11-0107. Epub 2011 Sep 27.
Although insulin resistance (IR) may underlie associations between depressive symptoms and diabetes, previous findings have been contradictory. We examined whether depressive symptoms associate with IR and insulin secretion, and, additionally, whether antidepressant medication use may modulate such associations.
A total of 4,419 individuals underwent an oral glucose tolerance test (OGTT). Participants with previously or newly diagnosed diabetes are excluded from this sample. The homeostasis model assessment of IR (HOMA-IR) and corrected insulin response (CIR) were calculated. Depressive symptoms and antidepressant medication use were self-reported.
After controlling for confounding factors, depressive symptoms were associated with higher fasting and 30-min insulin during the OGTT and higher HOMA-IR but not CIR. Antidepressant medication use failed to modify these associations.
Depressive symptoms are associated with IR but not with changes in insulin response when corrected for IR in individuals without previously or newly diagnosed diabetes.
尽管胰岛素抵抗（IR）可能是抑郁症状与糖尿病之间关联的基础，但先前的研究结果存在矛盾。我们研究了抑郁症状是否与 IR 和胰岛素分泌有关，以及抗抑郁药物的使用是否会调节这种关联。
共有 4419 人接受了口服葡萄糖耐量试验（OGTT）。本样本排除了先前或新诊断为糖尿病的患者。计算了胰岛素抵抗的稳态模型评估（HOMA-IR）和校正后的胰岛素反应（CIR）。抑郁症状和抗抑郁药物的使用情况是自我报告的。
在控制了混杂因素后，抑郁症状与 OGTT 期间的空腹和 30 分钟胰岛素更高以及 HOMA-IR 更高相关，但与 CIR 无关。抗抑郁药物的使用并未改变这些关联。
在没有先前或新诊断为糖尿病的个体中，抑郁症状与 IR 相关，但与校正 IR 后的胰岛素反应变化无关。
