Roos Camilla, Lidfeldt Jonas, Agardh Carl-David, Nyberg Per, Nerbrand Christina, Samsioe Göran, Westrin Asa
Department of Clinical Science, Division of Psychiatry, Lund University Hospital, SE-221 85 Lund, Sweden.
Metabolism. 2007 Jun;56(6):825-9. doi: 10.1016/j.metabol.2007.01.013.
Previous studies have suggested that depression increases the risk for diabetes and that this may be mediated through insulin resistance. The study aimed to analyze if self-rated symptoms of depression are related to insulin resistance among middle-aged and older Swedish women with features of the metabolic syndrome and being at risk for type 2 diabetes mellitus. We analyzed data from 1047 Swedish women aged 50 to 64 years without a history of diabetes and living in the southern part of Sweden. A variable self-rated symptoms of depression (SRSD) was defined by using the Gothenburg Quality of Life instrument. We estimated odds ratios (ORs) to determine whether or not SRSD was associated with the homeostasis model assessment of insulin resistance. The variable SRSD was not associated with insulin resistance. However, it was positively associated with waist-hip ratio (OR, 1.95; 95% confidence interval, 1.28-3.00) and negatively associated with physical exercise (OR, 1.29; 95% confidence interval, 0.99-1.68) after multivariate adjustment. In conclusion, lifestyle factors such as physical inactivity and abdominal obesity, but not insulin resistance, seem to be related to self-rated symptoms of depression in women with risk factors for diabetes mellitus. The relationship between insulin resistance and major depression needs to be further examined.
以往研究表明，抑郁症会增加患糖尿病的风险，且这可能通过胰岛素抵抗介导。该研究旨在分析在患有代谢综合征特征且有2型糖尿病风险的瑞典中老年女性中，自我评定的抑郁症状是否与胰岛素抵抗有关。我们分析了1047名年龄在50至64岁之间、无糖尿病病史且居住在瑞典南部的瑞典女性的数据。通过使用哥德堡生活质量量表定义了一个变量——自我评定的抑郁症状（SRSD）。我们估计比值比（OR）来确定SRSD是否与胰岛素抵抗的稳态模型评估相关。变量SRSD与胰岛素抵抗无关。然而，在多变量调整后，它与腰臀比呈正相关（OR，1.95；95%置信区间，1.28 - 3.00），与体育锻炼呈负相关（OR，1.29；95%置信区间，0.99 - 1.68）。总之，诸如缺乏体育活动和腹部肥胖等生活方式因素，而非胰岛素抵抗，似乎与有糖尿病风险因素的女性自我评定的抑郁症状有关。胰岛素抵抗与重度抑郁症之间的关系需要进一步研究。
