Pioneer Research Center for Nanogrid Materials, Department of Polymer Science and Engineering, Pusan National University, Busan, South Korea.
Chemistry. 2011 Nov 4;17(45):12802-8. doi: 10.1002/chem.201101110. Epub 2011 Sep 27.
Magnetic particles have become very promising materials for drug delivery. However, preparation of magnetite particles with high surface area, biocompatibility, strong magnetic response, and suitable particle size still remains a major challenge. In this report, magnetite nanocrystal clusters with high surface areas were fabricated through a solvothermal process by introducing ammonium acetate as a porogen and trisodium citrate as a surface modification agent. The porosity, which was controlled by the reactant concentration, has been investigated in detail. The surface area of the nanocrystal clusters was as high as 141 m(2) g(-1). Ibuprofen, as a model drug, was entrapped into the magnetite carriers. The interfacial interaction between the carboxylic groups on the drug molecules and the carboxylate groups on the carriers enhanced the loading efficiency. Low cytotoxicity in MCF-7 cell and in vitro constant drug release behavior combined with the high drug loading efficiency and high saturation magnetization values demonstrated the potential of the as-synthesized magnetite materials in targeted drug release systems.
磁性粒子已成为药物传递的很有前途的材料。然而，制备具有高表面积、生物相容性、强磁响应和合适粒径的磁铁矿颗粒仍然是一个主要挑战。在本报告中，通过溶剂热法制备了具有高表面积的磁铁矿纳米晶簇，方法是引入乙酸铵作为致孔剂和柠檬酸三钠作为表面改性剂。详细研究了反应物浓度控制的多孔性。纳米晶簇的比表面积高达 141 m(2) g(-1)。布洛芬作为模型药物被包封在磁铁矿载体中。药物分子上的羧酸基团与载体上的羧酸盐基团之间的界面相互作用提高了负载效率。在 MCF-7 细胞中的低细胞毒性和体外持续药物释放行为，加上高药物负载效率和高饱和磁化强度值，证明了所合成的磁铁矿材料在靶向药物释放系统中的潜力。
