Institute of Combined Injury, State Key Laboratory of Trauma, Burns and Combined Injury, Chongqing Engineering Research Center for Nanomedicine, College of Preventive Medicine, Third Military Medical University, 30 Gaotanyan Road, 400038, Chongqing, China.
Nanoscale. 2013 Aug 7;5(15):7026-33. doi: 10.1039/c3nr00931a.
Highly charged hydrophilic superparamagnetic Fe3O4 colloidal nanocrystal clusters with an average diameter of 195 nm have been successfully synthesized using a modified one-step solvothermal method. Anionic polyelectrolyte poly(4-styrenesulfonic acid-co-maleic acid) sodium salt containing both sulfonate and carboxylate groups was used as the stabilizer. The clusters synthesized under different experimental conditions were characterized with transmission electron microscopy and dynamic light scattering; it was found that the size distribution and water dispersity were significantly affected by the concentration of the polyelectrolyte stabilizer and iron sources in the reaction mixtures. A possible mechanism involving novel gel-like large molecular networks that confined the nucleation and aggregation process was proposed and discussed. The colloidal nanocrystal clusters remained negatively charged in the experimental pH ranges from 2 to 11, and also showed high colloidal stability in phosphate buffered saline (PBS) and ethanol. These highly colloidal stable superparamagnetic Fe3O4 clusters could find potential applications in bioseparation, targeted drug delivery, and photonics.
已成功使用改良的一步溶剂热法合成了平均直径为 195nm 的带高电荷的亲水性超顺磁 Fe3O4 胶态纳米晶簇。使用同时含有磺酸根和羧酸盐基团的阴离子型聚电解质聚（4-苯乙烯磺酸-co-马来酸）钠盐作为稳定剂。用透射电子显微镜和动态光散射法对在不同实验条件下合成的纳米晶簇进行了表征，发现纳米晶簇的尺寸分布和水分散性显著受反应混合物中聚电解质稳定剂和铁源浓度的影响。提出并讨论了一种涉及新型凝胶状大分子网络的可能机制，该网络限制了成核和聚集过程。在实验 pH 值范围为 2 到 11 时，胶体纳米晶簇保持带负电荷，在磷酸盐缓冲盐水 (PBS) 和乙醇中也表现出高胶体稳定性。这些高度稳定的胶体超顺磁 Fe3O4 纳米晶簇在生物分离、靶向药物输送和光子学方面可能具有潜在的应用。
