Department of Chemistry, Bogazici University, Bebek, Istanbul, 34342, Turkey.
Chem Asian J. 2011 Oct 4;6(10):2648-59. doi: 10.1002/asia.201100440. Epub 2011 Aug 29.
Hydrogels are crosslinked polymeric materials that play a vital role in many biomedical areas such as drug delivery, sensor technology, and tissue engineering. Increasing demand of these materials for such advanced applications has necessitated the development of hydrogels with complex chemical compositions such as incorporating small molecules and biomolecules that provide the functional attributes. This Focus Review highlights the tremendous impact of click chemistry on the design, synthesis, and functionalization of hydrogels. The high efficiency and fidelity of the click reactions have enabled rapid and modular synthesis of hydrogels with near-ideal network structures. Efficient incorporation of biomolecular building blocks, such as peptide sequences either during or after the fabrication of hydrogels, have been achieved through various click reactions. Utilization of these efficient reactions has led to the fabrication of many stimuli-responsive or 'smart' hydrogels in recent years.
水凝胶是交联的聚合物材料，在药物输送、传感器技术和组织工程等许多生物医学领域发挥着重要作用。由于这些材料在高级应用中的需求不断增加，因此需要开发具有复杂化学成分的水凝胶，例如掺入小分子和生物分子，以提供功能属性。本重点综述强调点击化学对水凝胶的设计、合成和功能化的巨大影响。点击反应的高效率和保真度使得具有近乎理想网络结构的水凝胶的快速和模块化合成成为可能。通过各种点击反应，可以在水凝胶的制造过程中或之后有效地掺入生物分子构建块，例如肽序列。近年来，这些高效反应的利用导致了许多刺激响应或“智能”水凝胶的制造。
