Yang Wanying, Wang Jiaqi, Jia Lingjiang, Li Jingyi, Liu Shouxin
Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi'an 710119, China.
Gels. 2023 Aug 11;9(8):647. doi: 10.3390/gels9080647.
Stimulus-responsive hydrogels have been widely used in the field of drug delivery because of their three-dimensional pore size and the ability to change the drug release rate with the change in external environment. In this paper, the temperature-sensitive monomer 2-methyl-2-acrylate-2-(2-methoxyethoxy-ethyl) ethyl ester (MEOMA) and oligoethylene glycol methyl ether methacrylate (OEGMA) as well as the pH-sensitive monomer ,-Diethylaminoethyl methacrylate (DEAEMA) were used to make the gel with temperature and pH response. Four kinds of physicochemical double-crosslinked amphiphilic co-network gels with different polymerization degrees were prepared by the one-pot method using the stereocomplex between polylactic acid as physical crosslinking and click chemistry as chemical crosslinking. By testing morphology, swelling, thermal stability and mechanical properties, the properties of the four hydrogels were compared. Finally, the drug release rate of the four gels was tested by UV-Vis spectrophotometer. It was found that the synthetic hydrogels had a good drug release rate and targeting, and had great application prospect in drug delivery.
刺激响应性水凝胶因其三维孔径以及能够随外部环境变化改变药物释放速率而在药物递送领域得到广泛应用。本文采用温度敏感单体2-甲基-2-丙烯酸-2-(2-甲氧基乙氧基-乙基)乙酯(MEOMA)、聚乙二醇甲基丙烯酸甲酯(OEGMA)以及pH敏感单体甲基丙烯酸二乙氨基乙酯(DEAEMA)制备具有温度和pH响应的凝胶。以聚乳酸之间的立体复合物作为物理交联、点击化学作为化学交联，通过一锅法制备了四种不同聚合度的物理化学双交联两亲性共网络凝胶。通过测试形态、溶胀、热稳定性和力学性能，对四种水凝胶的性能进行了比较。最后，用紫外可见分光光度计测试了四种凝胶的药物释放速率。结果发现，合成的水凝胶具有良好的药物释放速率和靶向性，在药物递送方面具有广阔的应用前景。
