一种小分子通过磷酸化周期蛋白来调节生物钟节律。
A small molecule modulates circadian rhythms through phosphorylation of the period protein.
机构信息
Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
出版信息
Angew Chem Int Ed Engl. 2011 Nov 4;50(45):10608-11. doi: 10.1002/anie.201103915. Epub 2011 Sep 26.
Abstract
A high-throughput cell-based screen identified a benzothiazole analogue, LH846, which induces period lengthening of the circadian rhythm. Affinity chromatography coupled with mass spectrometry and genomic analysis identified protein kinase CKIδ as the biological target of LH846 (see picture).
摘要
高通量基于细胞的筛选发现了一种苯并噻唑类似物 LH846，它能诱导生物钟周期延长。亲和层析结合质谱和基因组分析鉴定蛋白激酶 CKIδ 为 LH846 的生物靶标（见图）。
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