Evirgen O, Onlen Y, Ertan O
Department of Infectious Diseases and Clinical Microbiology, Mustafa Kemal University, School of Medicine, Hatay, Turkey.
Bratisl Lek Listy. 2011;112(10):595-8.
In the present study, we intended to investigate the intensity of antibiotic administration in our hospital and the ratio of an inappropriate antibiotic usage.
Related data was collected during 3 consecutive days between 1-3 July 2009 at the Mustafa Kemal University, Faculty of Medicine Hospital. The antimicrobial usage was calculated as defined daily doses (DDDs) per 100 bed-days (BD) according to 2009 ATC-DDD index.
Antibiotics were administered to 74 patients (61.5%) out of 121 who were hospitalized in our hospital. Antibiotic usage in the internal clinics was intended for therapeutical reasons in 18 patients (94.7%) and for prophylactic reasons in 35 patients (77.8%) in the surgical clinics. The use of antibiotics in 44 patients (59.7%) out of 74 was appropriate. However, an inappropriate antibiotic use was detected in 30 patients (40.5%). The inappropriate antibiotics were administered to 21 patients (70%) who were hospitalized in the surgical clinics. A three days total antimicrobial consumption index value in the hospital was 81,19 DDD/100 BD, while this value was found 25,45 DDD/100 BD for the internal clinics and 38,39 DDD/100 BD for the surgical clinics. A positive correlation was observed among the inappropriate antibiotic usage and the antibiotic consumption (p<0.001).
Consequently, the ratio of an inappropriate antibiotic usage in our hospital is high and parallel to this, the antibiotic consumption ratio is excessive. It is necessary to share microbiological data and provide an adequate education to reduce the antibiotic consumption and enable a better and rational antibiotic consumption (Tab. 2, Fig. 2, Ref. 22).
在本研究中，我们旨在调查我院抗生素的使用强度以及不适当抗生素使用的比例。
于2009年7月1日至3日在穆斯塔法·凯末尔大学医学院医院连续3天收集相关数据。根据2009年的《解剖学治疗学化学分类系统-限定日剂量》索引，抗菌药物的使用量以每100床日（BD）的限定日剂量（DDD）来计算。
在我院住院的121名患者中，有74名（61.5%）接受了抗生素治疗。内科门诊使用抗生素的原因中，18名患者（94.7%）是出于治疗目的，外科门诊35名患者（77.8%）是出于预防目的。74名使用抗生素的患者中，44名（59.7%）的使用是恰当的。然而，在30名患者（40.5%）中检测到存在不适当的抗生素使用情况。不适当的抗生素用于21名（70%）住院于外科门诊的患者。医院三天的总抗菌药物消耗指数值为81.19 DDD/100 BD，而内科门诊该值为25.45 DDD/100 BD，外科门诊为38.39 DDD/100 BD。在不适当的抗生素使用与抗生素消耗之间观察到正相关（p<0.001）。
因此，我院不适当抗生素使用的比例较高，与此平行的是，抗生素消耗比例过高。有必要共享微生物学数据并提供充分的教育，以减少抗生素消耗并实现更好且合理的抗生素使用（表2，图2，参考文献22）。
