Wu Hongfei, Lu Chuanhua, Zhou An, Min Zhiwei, Zhang Yulian
Department of Pharmaceutics, Anhui University of Traditional Chinese Medicine, Anhui Province Key Laboratory of R&D of Chinese Medicine, Hefei, P.R. China.
Drug Dev Ind Pharm. 2009 Feb;35(2):138-44. doi: 10.1080/03639040801973495.
The main purpose of this study was to prepare puerarin microemulsion system to improve oral bioavailability of puerarin. The microemulsion formulations were prepared using soybean oil, soybean lecithin/ethyl lactate (1:1), and 1,2-propanediol/water. The presence of microemulsion regions were investigated by pseudo-ternary phase diagrams. The droplet size of microemulsion was characterized by photo-correlation spectroscopy. In vivo pharmacokinetic study was conducted in mice, and the results indicated that AUC(0-->infinity) was 15.82-fold higher than that of puerarin suspension upon oral administration. Particles of puerarin microemulsion were round and homogeneous. Puerarin microemulsion also showed good stability. These studies showed that microemulsion system of puerarin might be promising vehicles for the peroral delivery of puerarin.
本研究的主要目的是制备葛根素微乳体系以提高葛根素的口服生物利用度。微乳制剂采用大豆油、大豆卵磷脂/乳酸乙酯（1:1）以及1,2 - 丙二醇/水制备而成。通过拟三元相图研究微乳区域的存在情况。利用光散射光谱法对微乳的粒径进行表征。在小鼠体内进行了药代动力学研究，结果表明口服给药后，葛根素微乳的AUC(0→∞)比葛根素混悬液高15.82倍。葛根素微乳的颗粒呈圆形且均匀。葛根素微乳还表现出良好的稳定性。这些研究表明，葛根素微乳体系可能是葛根素口服给药的有前景的载体。
