Centre for Addictions Research of British Columbia, University of Victoria, Victoria, BC, Canada.
Drug Alcohol Rev. 2012 Mar;31(2):126-34. doi: 10.1111/j.1465-3362.2011.00342.x. Epub 2011 Sep 29.
Low-risk drinking guidelines have been developed independently in a number of jurisdictions resulting in different sets of advice with different definitions of 'low risk'. This paper discusses some of the fundamental issues addressed by an expert advisory panel during the course of developing national guidelines for Canadians and summarises key sets of evidence that were influential.
The underlying reasoning and connection between the evidence and the guidelines is discussed in relation to: (i) how to minimise risk of long-term illnesses; (ii) how to minimise risk of short-term harms, for example injury; and (iii) alcohol use during pregnancy. Both absolute and relative risks were considered in the development of the guidelines.
Meta-analyses of all-cause mortality were used to identify upper limits for usual drinking levels where potential benefits and risks were balanced for the average person in comparison with lifetime abstainers (10 standard drinks per week for women, 15 for men). Emergency room studies and situational risk factors were considered for advice on reducing short-term: (i) when not to drink at all; (ii) how to reduce intoxication; and (iii) upper limits for occasional daily consumption by adults aged 25 to 64 years (3 standard drinks for women, 4 for men). Shortcomings in the research data were highlighted.
It was estimated that total compliance with these guidelines at a national level would result in substantially reduced per capita alcohol consumption and approximately 4600 fewer deaths per year.
在多个司法管辖区中,已经独立制定了低风险饮酒指南,导致了不同的建议和不同的“低风险”定义。本文讨论了在为加拿大人制定国家指南的过程中,一个专家咨询小组所涉及的一些基本问题,并总结了具有影响力的关键证据。
本文讨论了证据与指南之间的基本推理和联系,涉及:(i)如何最大程度地降低长期疾病的风险;(ii)如何最大程度地降低短期伤害的风险,例如受伤;以及(iii)怀孕期间的饮酒。在制定指南时,同时考虑了绝对风险和相对风险。
使用全因死亡率的荟萃分析来确定通常饮酒水平的上限,在这些水平上,与终身戒酒者相比,普通人的潜在收益和风险达到平衡(女性每周 10 标准饮料,男性每周 15 标准饮料)。考虑了急诊室研究和情境风险因素,以提供有关减少短期风险的建议:(i)何时完全不饮酒;(ii)如何减少醉酒;以及(iii)25 至 64 岁成年人偶尔每天饮酒的上限(女性 3 标准饮料,男性 4 标准饮料)。研究数据的不足之处被强调。
据估计,在全国范围内完全遵守这些指南,将导致人均酒精消费量大幅下降,每年减少约 4600 人死亡。