Department of Dermatology, School of Medicine, Pusan National University, Busan, Korea.
J Dermatol. 2011 Dec;38(12):1135-9. doi: 10.1111/j.1346-8138.2011.01223.x. Epub 2011 Sep 28.
Rosacea is a common inflammatory skin disorder; the pathogenesis is unclear. Various treatment options for rosacea are available, but most have limited effectiveness. The aim of this study was to investigate the efficacy and safety of 1% pimecrolimus cream for the treatment of rosacea. Thirty patients with rosacea were enrolled in this 4-week, single-center, open-label study of 1% pimecrolimus cream. Patients were instructed to apply the cream to their faces twice daily and were not permitted to use any other agents. Clinical efficacy was evaluated by a rosacea grading system using photographic documentation and a mexameter. The 26 patients who completed the study experienced significantly reduced rosacea clinical scores from 9.65 ± 1.79 at baseline to 7.27 ± 2.11 at the end of treatment (P < 0.05). The mexameter-measured erythema index decreased significantly from 418.54 ± 89.56 at baseline to 382.23 ± 80.04 at week 4 (P < 0.05). The side-effects were mostly transient local irritations. The results of this study suggest that 1% pimecrolimus cream is an effective and well-tolerated treatment for patients with mild to moderate inflammatory rosacea.
酒渣鼻是一种常见的炎症性皮肤疾病，其发病机制尚不清楚。目前有多种治疗酒渣鼻的方法可供选择，但大多数方法的疗效有限。本研究旨在探讨 1%吡美莫司乳膏治疗酒渣鼻的疗效和安全性。
30 例酒渣鼻患者参与了这项为期 4 周、单中心、开放性的 1%吡美莫司乳膏研究。患者被指示每天将乳膏涂抹于面部两次，并且不得使用任何其他药物。临床疗效通过拍照记录和 mexameter 评估酒渣鼻分级系统进行评估。
完成研究的 26 例患者的酒渣鼻临床评分从基线时的 9.65 ± 1.79 显著降低至治疗结束时的 7.27 ± 2.11（P < 0.05）。mexameter 测量的红斑指数从基线时的 418.54 ± 89.56 显著降低至第 4 周时的 382.23 ± 80.04（P < 0.05）。副作用主要为短暂的局部刺激。
本研究结果表明，1%吡美莫司乳膏是治疗轻中度炎症性酒渣鼻患者的一种有效且耐受性良好的治疗方法。
