Division of General Medicine, Taipei Medical University Shuang Ho Hospital, New Taipei, Taiwan.
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Front Immunol. 2024 Jul 29;15:1403798. doi: 10.3389/fimmu.2024.1403798. eCollection 2024.
Rosacea is a complex inflammatory condition characterized by papulopustular lesions and erythema on the central face for which there is no cure. The development of rosacea is influenced by both external triggers and genetics, but the common pathophysiology is overactivation of the immune system. Here, we review the current data on proinflammatory cytokines and dysregulation of the neurovascular system as targetable components of rosacea. Amelioration of cutaneous and gastrointestinal dysbiosis and other external factors impacts the immune state and has been observed to improve rosacea. While multiple treatments exist, many patients do not achieve their goals for rosacea control and highlights an unmet need for dermatologic care. Current interventions encompass topical/oral drugs, light devices, and avoidance of triggers management. Additional understanding of the underlying pathogenesis may help us develop novel targeted therapeutic strategies to improve rosacea.
酒渣鼻是一种复杂的炎症性疾病，表现为面部中央的丘疹脓疱性皮损和红斑，但目前尚无治愈方法。酒渣鼻的发生受外部诱因和遗传因素的影响，但共同的病理生理学是免疫系统过度激活。在这里，我们回顾了目前关于促炎细胞因子和神经血管系统失调作为酒渣鼻靶点的研究数据。改善皮肤和胃肠道的微生态失调和其他外部因素会影响免疫状态，并已观察到可改善酒渣鼻。虽然有多种治疗方法，但许多患者并未达到控制酒渣鼻的目标，这突显了皮肤科护理的未满足需求。目前的干预措施包括局部/口服药物、光设备和避免触发因素的管理。对潜在发病机制的进一步了解可能有助于我们开发新的靶向治疗策略来改善酒渣鼻。
